Effect of weight loss on QTc dispersion in obese subjects
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Tarih
2006
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Artmış QTc dispersiyonu ventriküler aritmiler için bir göstergedir. Bu çalışmanın amacı diyet ve medikal tedavi ile kilo kaybı programı sonrası QTc dispersiyonunun azalmasını araştırmaktır. Yöntemler: Bu çalışmaya 12 haftalık kilo kaybı programı sonrası mevcut kilolarının en az %10'nu veren 30 (24 kadın ve 6 erkek, ort. yaş: 44±8 yıl) obez birey dahil edildi. Obezite vücut kitle indeksi'nin (VKİ) ?30 kg/m2 olarak tarif edildi. Normal kilo ise VKİ'nin ? 25 kg/m2 olarak tarif edildi. Bulgular: On iki haftalık kilo kaybı programı sonrası, VKİ 42±5 kg/m2'den 36±4 kg/m2 (p<0.001) azaldı ve obez bireylerin ortalama ağırlığı 110±17 kg'dan 95±15 kg (p<0.001) azaldı. Kilo kaybının ortalama miktarı 14.5±5.0 kg (9-32 kg arasında) idi. Kilo kaybının ortalama yüzdesi ise 13% (10.0%-20.3%) idi. Maksimum QTc interval (446±19 ms'den 433±27 ms, p=0.024) ve QTc dispersiyonu (66±18 ms'den 52±25 ms, p=0.024) kilo kaybı programı sonrası önemli oranda azaldı. QTc dispersiyonun seviyesindeki azalma ile kilo kaybının miktarı arasında istatistiksel olarak anlamlı ilişki bulundu (r=0.487, p=0.007). Sonuç: Obez bireylerde önemli kilo kaybı QTc dispersiyon seviyesini önemli oranda azaltmıştır. QTc dispersiyon azalmasının derecesi kilo kaybının miktarı ile ilişkilidir.
Objective: Increased QTc dispersion is a predictor for ventricular arrhythmias. The aim of this study was to investigate whether QTc dispersion decreases after weight loss program with diet and medical treatment. Methods: Total 30 (24 women and 6 men, mean age: 44±8 years) obese subjects who lost at least 10% of their original weight after 12 week weight loss program were included in present study. Obesity was defined as &#8805;30 kg/m2 of body mass index (BMI). Normal weight was defined as &#8804; 25 kg/m2 of BMI. Results: After 12 week weight loss program, BMI decreased from 42±5 kg/m2 to 36±4 kg/m2 (p<0.001) and mean weight of obese subjects decreased from 110±17 kg to 95±15 kg (p<0.001). The mean amount of weight loss was 14.5±5.0 kg (range 9-32 kg). The average percent of weight loss was 13% (10.0%-20.3%). Maximum QTc interval (from 446±19 ms to 433±27 ms, p=0.024) and QTc dispersion (from 66±18 ms to 52±25 ms, p=0.024) significantly decreased after weight loss program. A statistically significant correlation was found between decrease in level of QTc dispersion and amount of weight loss (r=0.487, p=0.007). Conclusion: Substantial weight loss in obese subjects is accompanied by significantly decreased QTc dispersion. The degree of QTc dispersion reduction is associated with amount of weight loss.
Objective: Increased QTc dispersion is a predictor for ventricular arrhythmias. The aim of this study was to investigate whether QTc dispersion decreases after weight loss program with diet and medical treatment. Methods: Total 30 (24 women and 6 men, mean age: 44±8 years) obese subjects who lost at least 10% of their original weight after 12 week weight loss program were included in present study. Obesity was defined as &#8805;30 kg/m2 of body mass index (BMI). Normal weight was defined as &#8804; 25 kg/m2 of BMI. Results: After 12 week weight loss program, BMI decreased from 42±5 kg/m2 to 36±4 kg/m2 (p<0.001) and mean weight of obese subjects decreased from 110±17 kg to 95±15 kg (p<0.001). The mean amount of weight loss was 14.5±5.0 kg (range 9-32 kg). The average percent of weight loss was 13% (10.0%-20.3%). Maximum QTc interval (from 446±19 ms to 433±27 ms, p=0.024) and QTc dispersion (from 66±18 ms to 52±25 ms, p=0.024) significantly decreased after weight loss program. A statistically significant correlation was found between decrease in level of QTc dispersion and amount of weight loss (r=0.487, p=0.007). Conclusion: Substantial weight loss in obese subjects is accompanied by significantly decreased QTc dispersion. The degree of QTc dispersion reduction is associated with amount of weight loss.
Açıklama
Anahtar Kelimeler
Kalp ve Kalp Damar Sistemi
Kaynak
Anadolu Kardiyoloji Dergisi
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N/A
Cilt
6
Sayı
2
