The Effects of High Calcium and Vitamin D on the Fructose- Induced Lipogenesis Pathway in Rats

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dc.contributor.authorKara, Semiha Özge
dc.contributor.authorYakan, Akın
dc.date.accessioned2024-09-19T16:23:31Z
dc.date.available2024-09-19T16:23:31Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIn this study, the protective effects of high amounts of dietary calcium and vitamin D on fructose-induced lipogenesis were investigated at molecular and biochemical levels. Control group (Con, n=8), High fructose diet group (F, n=8), High fructose diet+75 mg CaCO3 and 26.4 IU vitamin D3 group (FCaD1, n=8), High fructose diet+150 mg CaCO3 and 52.8 IU vitamin D3 group (FCaD2, n=8) including experimental groups were fed for 28 days. The significant difference between the living weights was determined firstly as 278.64±5.61a; 268.94±2.80ab; 257.93±4.86b and 257.38±3.42b g in the Con, F, FCaD1, FCaD2 groups, respectively, at the end of the first week (P<0.05). This difference was seen to persist during the 3rd week of the trial. It was observed that this difference continued until the end of the 3rd week of the study. In the study, plasma Triglyceride (TG) amount was found to be in the form of 36.25±2.76b; 99.13±15.63a; 98.50±18.00a and 79.88±9.33ab mg.dl-1 in Con, F, FCaD1 and FCaD2 groups, respectively (P<0.05). The SCD-1 gene's liver expression levels were assessed as 11.83±2.08 (P<0.001); 5.31±1.40 (P<0.05) and 5.18±1.43 (P<0.05), respectively, compared to the Con group; SREBP-1c was determined as 2.11±0.37 (P<0.05); 3.41±1.20 (P<0.05) and 1.79±0.30 (P<0.05), respectively. In this study, it has been shown through the SREBP-1c and SCD-1 genes that calcium-vitamin D supplementation can have positive effects in a short time against lipogenesis induced by high fructose diet.en_US
dc.identifier.doi10.30607/kvj.1319111
dc.identifier.endpage555en_US
dc.identifier.issn1308-1594
dc.identifier.issn2147-6853
dc.identifier.issue4en_US
dc.identifier.startpage541en_US
dc.identifier.trdizinid1221473en_US
dc.identifier.urihttps://doi.org/10.30607/kvj.1319111
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1221473
dc.identifier.urihttps://hdl.handle.net/20.500.12483/15928
dc.identifier.volume16en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofKocatepe Veterinary Journalen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCalciumen_US
dc.subjectFructoseen_US
dc.subjectLipogenesisen_US
dc.subjectLiveren_US
dc.subjectVitamin Den_US
dc.titleThe Effects of High Calcium and Vitamin D on the Fructose- Induced Lipogenesis Pathway in Ratsen_US
dc.typeArticleen_US

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