Prokinetics stimulate the increase of ghrelin in mice

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Date

2016

Journal Title

Journal ISSN

Volume Title

Publisher

Comenius Univ

Access Rights

info:eu-repo/semantics/openAccess

Abstract

OBJECTIVES: Intestinal motility is regulated by several neurotransmitters and neuropeptides including dopamine and acetylcholine as well as ghrelin. Metoclopramide and domperidone are long-standing treatment options for dysmotility, and erythromycin is suggested in selected patients. In the present study, we aimed to investigate the effects of mentioned prokinetics on ghrelin levels. METHODS: Serum ghrelin levels were estimated by using enzyme-linked immunoassay following a single administration of domperidone, metoclopramide, or erythromycin. RESULTS: Our results showed that both antidopaminergic and cholinergic prokinetics increase the circulating ghrelin levels. There was no significant difference between enteral and parenteral control groups. Also, statistical analysis revealed that neither prokinetic was superior to the other in regard to its ghrelin stimulating effect. CONCLUSION: Conclusively, the present study demonstrated that the circulating levels of ghrelin increase by the administration of antidopaminergic and cholinergic prokinetics. Hence, this effect on ghrelin may partly be responsible for the motility-stimulating actions of domperidone, metoclopramide, and erythromycin (Fig. 2, Ref. 39). Text in PDF www.elis.sk.

Description

Keywords

domperidone, erythromycin, ghrelin, metoclopramide, prokinetics

Journal or Series

Bratislava Medical Journal-Bratislavske Lekarske Listy

WoS Q Value

Q3

Scopus Q Value

Q2

Volume

117

Issue

12

Citation