Prokinetics stimulate the increase of ghrelin in mice

Basit Öğe Kaydı
dc.authoridDemir, Enver/0000-0002-2620-6192
dc.contributor.authorSagkan-Ozturk, A.
dc.contributor.authorDemir, E. A.
dc.contributor.authorOzturk, A.
dc.date.accessioned2024-09-18T20:15:19Z
dc.date.available2024-09-18T20:15:19Z
dc.date.issued2016
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractOBJECTIVES: Intestinal motility is regulated by several neurotransmitters and neuropeptides including dopamine and acetylcholine as well as ghrelin. Metoclopramide and domperidone are long-standing treatment options for dysmotility, and erythromycin is suggested in selected patients. In the present study, we aimed to investigate the effects of mentioned prokinetics on ghrelin levels. METHODS: Serum ghrelin levels were estimated by using enzyme-linked immunoassay following a single administration of domperidone, metoclopramide, or erythromycin. RESULTS: Our results showed that both antidopaminergic and cholinergic prokinetics increase the circulating ghrelin levels. There was no significant difference between enteral and parenteral control groups. Also, statistical analysis revealed that neither prokinetic was superior to the other in regard to its ghrelin stimulating effect. CONCLUSION: Conclusively, the present study demonstrated that the circulating levels of ghrelin increase by the administration of antidopaminergic and cholinergic prokinetics. Hence, this effect on ghrelin may partly be responsible for the motility-stimulating actions of domperidone, metoclopramide, and erythromycin (Fig. 2, Ref. 39). Text in PDF www.elis.sk.en_US
dc.description.sponsorshipMustafa Kemal University Scientific Research Projects Coordination Unit [14480]en_US
dc.description.sponsorshipThis study has been supported by the Mustafa Kemal University Scientific Research Projects Coordination Unit (#14480).en_US
dc.identifier.doi10.4149/BLL_2016_139
dc.identifier.endpage729en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue12en_US
dc.identifier.pmid28127970en_US
dc.identifier.scopus2-s2.0-85014991694en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage726en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2016_139
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9566
dc.identifier.volume117en_US
dc.identifier.wosWOS:000392564800008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectdomperidoneen_US
dc.subjecterythromycinen_US
dc.subjectghrelinen_US
dc.subjectmetoclopramideen_US
dc.subjectprokineticsen_US
dc.titleProkinetics stimulate the increase of ghrelin in miceen_US
dc.typeArticleen_US

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