Antibiotic Resistance and Investigation of IMP-1, IMP-2, VIM-1 and VIM-2 Metallo-?-Lactamases in Acinetobacter Strains Isolated From Clinical Samples
Yükleniyor...
Dosyalar
Tarih
2015
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Aves
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: It was aimed to investigate the presence of metallo-beta-lactamase (MBL) production and bla (IMP-1), bla (IMP-2,) bla (VIM-1) and bla (VIM-2) genes in Acinetobacter strains isolated from clinical samples. Methods: 150 Acinetobacter strains isolated from clinical samples which were sent to microbiology laboratory from March 2009 to June 2012 were included in the study. The antimicrobial susceptibilities of the strains were determined using automated system, and production of metallo-beta-lactamase was investigated via Etest (R). Polymerase chain reaction (PCR) method was used for determining the bla (IMP-1), bla (IMP-2), bla (VIM-1) and bla (VIM-2) genes. Results: 94% of strains were Acinetobacter baumannii and, 6% of strains were A. lwoffii. The strains were mostly susceptible to gentamicin (41.3%), amikacin (36.7%), and imipenem (25.3%), while they were resistant to ceftriaxone (92%), levofloxacin (84.7%), ceftazidime (84%), and piperacillintazobactam (84%). Sixty seven (44.7%) of the strains were MBL-positive via Etest (R), and these strains were detected more resistant to imipenem, meropenem, ceftazidime, and ceftriaxone. No bla (IMP-1), bla (IMP-2), bla (VIM-1) and bla (VIM-2) genes were detected. Conclusions: While MBL production was detected in 44.7% of Acinetobacter strains, bla (IMP-1), bla (IMP-2,) bla (VIM-1) and bla (VIM-2) genes were not determined.
Açıklama
Anahtar Kelimeler
Acinetobacter, IMP-1, IMP-2, VIM-1, VIM-2, metallo-beta-lactamase, microbial drug resistance
Kaynak
Klimik Journal
WoS Q Değeri
N/A
Scopus Q Değeri
Q4
Cilt
28
Sayı
1
