Antibiotic Resistance and Investigation of IMP-1, IMP-2, VIM-1 and VIM-2 Metallo-?-Lactamases in Acinetobacter Strains Isolated From Clinical Samples

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dc.contributor.authorOcak, Merve
dc.contributor.authorOzer, Burcin
dc.contributor.authorInci, Melek
dc.contributor.authorDuran, Nizami
dc.date.accessioned2024-09-18T19:48:03Z
dc.date.available2024-09-18T19:48:03Z
dc.date.issued2015
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: It was aimed to investigate the presence of metallo-beta-lactamase (MBL) production and bla (IMP-1), bla (IMP-2,) bla (VIM-1) and bla (VIM-2) genes in Acinetobacter strains isolated from clinical samples. Methods: 150 Acinetobacter strains isolated from clinical samples which were sent to microbiology laboratory from March 2009 to June 2012 were included in the study. The antimicrobial susceptibilities of the strains were determined using automated system, and production of metallo-beta-lactamase was investigated via Etest (R). Polymerase chain reaction (PCR) method was used for determining the bla (IMP-1), bla (IMP-2), bla (VIM-1) and bla (VIM-2) genes. Results: 94% of strains were Acinetobacter baumannii and, 6% of strains were A. lwoffii. The strains were mostly susceptible to gentamicin (41.3%), amikacin (36.7%), and imipenem (25.3%), while they were resistant to ceftriaxone (92%), levofloxacin (84.7%), ceftazidime (84%), and piperacillintazobactam (84%). Sixty seven (44.7%) of the strains were MBL-positive via Etest (R), and these strains were detected more resistant to imipenem, meropenem, ceftazidime, and ceftriaxone. No bla (IMP-1), bla (IMP-2), bla (VIM-1) and bla (VIM-2) genes were detected. Conclusions: While MBL production was detected in 44.7% of Acinetobacter strains, bla (IMP-1), bla (IMP-2,) bla (VIM-1) and bla (VIM-2) genes were not determined.en_US
dc.identifier.doi10.5152/kd.2015.05
dc.identifier.endpage27en_US
dc.identifier.issn1301-143X
dc.identifier.issn1309-1484
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84946887253en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage23en_US
dc.identifier.urihttps://doi.org/10.5152/kd.2015.05
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7327
dc.identifier.volume28en_US
dc.identifier.wosWOS:000420958500005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherAvesen_US
dc.relation.ispartofKlimik Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcinetobacteren_US
dc.subjectIMP-1en_US
dc.subjectIMP-2en_US
dc.subjectVIM-1en_US
dc.subjectVIM-2en_US
dc.subjectmetallo-beta-lactamaseen_US
dc.subjectmicrobial drug resistanceen_US
dc.titleAntibiotic Resistance and Investigation of IMP-1, IMP-2, VIM-1 and VIM-2 Metallo-?-Lactamases in Acinetobacter Strains Isolated From Clinical Samplesen_US
dc.typeArticleen_US

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