The Protective Effect of Rutin Against Methotrexate-Induced Nephrotoxicity in Rats

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dc.contributor.authorTambag, Ali Kazim
dc.contributor.authorKazak, Filiz
dc.contributor.authorAkalin, Pinar Peker
dc.contributor.authorKutlu, Tuncer
dc.date.accessioned2024-09-18T20:32:49Z
dc.date.available2024-09-18T20:32:49Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: This study was purposed to investigate the possible protective effects of rutin on kidney tissue in a methotrexate-induced nephrotoxicity rat model. Methods: Rats were randomly divided into 4 groups: control group, methotrexate (MTX, 20 mg/kg) group, rutin (RUT, 50 mg/kg/day) group, and methotrexate + rutin (MTX+RUT, 20 mg/kg + 50 mg/kg/day, respectively) group. Biochemical and histopathological analyzes were performed on kidney tissues of rats at the end of the study. Results: It was determined that kidney tissue damage determined in the MTX group was decreased in the MTX + RUT group; there were no degenerative changes in the tubular epithelium of the MTX + RUT group, and only mild degenerative changes were observed rather than hydropic degeneration seen in MTX group. Conclusion: This study suggests that rutin can be effective in preventing the toxic effects of methotrexate on the kidney.en_US
dc.identifier.doi10.5152/turkjnephrol.2021.4731
dc.identifier.endpage223en_US
dc.identifier.issn2667-4440
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85112027400en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage218en_US
dc.identifier.trdizinid455444en_US
dc.identifier.urihttps://doi.org/10.5152/turkjnephrol.2021.4731
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/455444
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11150
dc.identifier.volume30en_US
dc.identifier.wosWOS:000681656200005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofTurkish Journal of Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMethotrexateen_US
dc.subjectnephrotoxicityen_US
dc.subjectrutinen_US
dc.titleThe Protective Effect of Rutin Against Methotrexate-Induced Nephrotoxicity in Ratsen_US
dc.typeArticleen_US

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