Investigations on hard gelatin capsules containing ampicillin beads

Basit Öğe Kaydı
dc.authorscopusid8644922600
dc.authorscopusid58038569600
dc.authorscopusid8644922200
dc.authorscopusid57212820770
dc.authorscopusid7004656210
dc.authorscopusid7004027425
dc.contributor.authorSahin, Nefise Ozlen
dc.contributor.authorErdogan, C.
dc.contributor.authorTeke, B.
dc.contributor.authorYuksel, A.
dc.contributor.authorSoylu, Soner
dc.contributor.authorSerin, M. Sami
dc.date.accessioned2024-09-19T15:41:31Z
dc.date.available2024-09-19T15:41:31Z
dc.date.issued2005
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe aim of this study is to develop hard gelatin capsules for better delivery of controlled release system bearing ampicillin. Rather than using plain drug to fill into the capsules, ampicillin was first encapsulated in alginate beads to provide controlled release behavior and then, these beads were placed in the capsules. The release of the drug occurred both by diffusion and erosion. %68 of ampicillin was released within the first 4 hours in the stomach and then, the rest of the drug was released in phosphate buffer of pH 7.4 within 2.6 hours. Microbiological assay indicated that the beads are effective. In conclusion, hard gelatin capsules containing alginate beads can be used for oral delivery of ampicillin to provide systemic effect for the treatment of infections.en_US
dc.identifier.endpage232en_US
dc.identifier.issn0428-0296
dc.identifier.issue1.Şuben_US
dc.identifier.scopus2-s2.0-21244447612en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage229en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14306
dc.identifier.volume52en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofPharmaciaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlginate beadsen_US
dc.subjectAmpicillinen_US
dc.subjectControlled drug deliveryen_US
dc.subjectHard gelatin capsulesen_US
dc.subjectIntestinal infectionsen_US
dc.titleInvestigations on hard gelatin capsules containing ampicillin beadsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu