BIOLOGICAL ACTIVITY EVALUATION OF THREE Hypericum L. SPECIES

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dc.authoridCevik, Ozge/0000-0002-9325-3757
dc.authoridAtas, Mehmet/0000-0002-9425-0080
dc.authorid, Nuraniye/0000-0002-4674-7009
dc.contributor.authorEruygur, Nuraniye
dc.contributor.authorOzpinar, Necati
dc.contributor.authorOzpinar, Hulya
dc.contributor.authorAtas, Mehmet
dc.contributor.authorTekin, Mehmet
dc.contributor.authorCevik, Ozge
dc.date.accessioned2024-09-18T20:27:55Z
dc.date.available2024-09-18T20:27:55Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThis study was performed in order to evaluate in vitro antioxidant, anti-Trichomonas vaginalis, antimicrobial and cytotoxic activities of methanol extracts of aerial parts of Hypericum perforatum L., H. thymbrifolium Boiss. & Noe and H. thymopsis Boiss. The antioxidant activity of methanol extracts was tested with 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2 '-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging and iron chelating assays. The total phenol and flavonoid contents were also determined spectrophotometrically. Cytotoxicity and apoptosis were evaluated on MCF-7 breast cancer and PC3 prostate cancer cell line. Antimicrobial activities were evaluated by the microdilution method on the bacterial strains Staphylococcus aureus (ATCC 29213), Enterococcus faecalis (ATCC 29212), Pseudomonas aeruginosa (ATCC 27853) Escherichia coli (ATCC 25922) and the fungal strain Candida albicans (ATCC 10231). All extracts demonstrated cytotoxic activity on PC3 prostat cancer cell line with a concentration dependent manner, while H. thymopsis extract was the most active against cancer cell growth. The obtained results of the present study revealed that the methanol extract of H. perforatum, H. thymbrifolium and H. thymopsis have significant antioxidant and cytotoxic activities. The results provided the basic research data for further phytochemical and biological activity guided investigations on these species for identication and isolation of potential drug active compounds.en_US
dc.description.sponsorshipScientific Research Foundation of Sivas Cumhuriyet University; [ECZ-020]en_US
dc.description.sponsorshipFunding: The authors express their sincere gratitude to Scientific Research Foundation of Sivas Cumhuriyet University for their financial support of the study with the project number ECZ-020.en_US
dc.identifier.doi10.23902/trkjnat.1043241
dc.identifier.endpage134en_US
dc.identifier.issn2528-9691
dc.identifier.issue2en_US
dc.identifier.startpage125en_US
dc.identifier.trdizinid1134509en_US
dc.identifier.urihttps://doi.org/10.23902/trkjnat.1043241
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1134509
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10601
dc.identifier.volume23en_US
dc.identifier.wosWOS:000878534200002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherTrakya Univ Balkan Yerlesesi Enstituler Binasien_US
dc.relation.ispartofTrakya University Journal of Natural Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHypericum perforatumen_US
dc.subjectHypericum thymbrifoliumen_US
dc.subjectHypericum thymopsisen_US
dc.subjectAntioxidanten_US
dc.subjectAnti-Trichomonasen_US
dc.subjectAntimicrobialen_US
dc.subjectCytotoxicityen_US
dc.titleBIOLOGICAL ACTIVITY EVALUATION OF THREE Hypericum L. SPECIESen_US
dc.typeArticleen_US

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