The Effects of Omega-3 Supplementation on Serum Oxidative Stress Parameters in Experimental Periodontitis in an Animal Model
[ N/A ]
Tarih
2021
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Experimental studies suggest that omega-3 may be beneficial at preventing alveolar bone loss (ABL) by modulating host immune response. The aim of this study is to evaluate the effects of omega-3 supplementation on ABL and serum oxidative biomarkers in a ligature-induced periodontitis model. Twenty-four Wistar albino rats are divided into 3 groups: control (C, n = 8); ligature-induced periodontitis (L, n = 8); and omega-3 plus ligature-induced periodontitis (O+L, n = 8). All rats are fed with ad libitum diet, and O+L group is additionally supplemented with omega-3 fish oil by oral gavage for 44 days. Experimental periodontitis is induced by placement of ligatures around the maxillary second molars of rats in L and O+L groups. ABL is measured histomorphometrically and serum 8-hydroxy-2'-deoxyguanosine, total antioxidant capacity, and total oxidant status (TOS) are analyzed. ABL is higher in L and O+L groups than the C group. Omega-3 supplementation is significantly reduced ABL in group O+L, compared to L group. Furthermore, TOS levels are lower in O+L group than L group. It is suggested that omega-3 administration may reduce ABL and serum TOS levels, which supports the antioxidant role of omega-3 on periodontal disease pathogenesis. Practical applications: Adjunctive use of omega-3 supplementation in periodontitis seems beneficial, although biochemical mechanisms underlying the conflicting results have not been completely understood. On the other hand, oxidative stress has been used as an appropriate target for host modulation therapies in periodontal disease. Omega-3 supplementation in ligature-induced periodontitis in an animal model successfully reduces alveolar bone loss by modulating serum total oxidant status, which may provide a novel pathway in periodontal disease pathogenesis.
Açıklama
Anahtar Kelimeler
alveolar bone loss, fatty acids, omega-3, oxidative stress, periodontitis
Kaynak
European Journal of Lipid Science and Technology
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
123
Sayı
12
