The Effects of Omega-3 Supplementation on Serum Oxidative Stress Parameters in Experimental Periodontitis in an Animal Model

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dc.contributor.authorDogan, Burak
dc.contributor.authorDogan, Esra Sinem Kemer
dc.date.accessioned2024-09-18T19:54:15Z
dc.date.available2024-09-18T19:54:15Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractExperimental studies suggest that omega-3 may be beneficial at preventing alveolar bone loss (ABL) by modulating host immune response. The aim of this study is to evaluate the effects of omega-3 supplementation on ABL and serum oxidative biomarkers in a ligature-induced periodontitis model. Twenty-four Wistar albino rats are divided into 3 groups: control (C, n = 8); ligature-induced periodontitis (L, n = 8); and omega-3 plus ligature-induced periodontitis (O+L, n = 8). All rats are fed with ad libitum diet, and O+L group is additionally supplemented with omega-3 fish oil by oral gavage for 44 days. Experimental periodontitis is induced by placement of ligatures around the maxillary second molars of rats in L and O+L groups. ABL is measured histomorphometrically and serum 8-hydroxy-2'-deoxyguanosine, total antioxidant capacity, and total oxidant status (TOS) are analyzed. ABL is higher in L and O+L groups than the C group. Omega-3 supplementation is significantly reduced ABL in group O+L, compared to L group. Furthermore, TOS levels are lower in O+L group than L group. It is suggested that omega-3 administration may reduce ABL and serum TOS levels, which supports the antioxidant role of omega-3 on periodontal disease pathogenesis. Practical applications: Adjunctive use of omega-3 supplementation in periodontitis seems beneficial, although biochemical mechanisms underlying the conflicting results have not been completely understood. On the other hand, oxidative stress has been used as an appropriate target for host modulation therapies in periodontal disease. Omega-3 supplementation in ligature-induced periodontitis in an animal model successfully reduces alveolar bone loss by modulating serum total oxidant status, which may provide a novel pathway in periodontal disease pathogenesis.en_US
dc.description.sponsorshipHatay Mustafa Kemal University Scientific Research Projects Commission [18]en_US
dc.description.sponsorshipThis research was financially supported by the Hatay Mustafa Kemal University Scientific Research Projects Commission (Project number: 18.M.090). The authors are grateful to Mustafa Calapolu for the measurement of serum parameters.en_US
dc.identifier.doi10.1002/ejlt.202100102
dc.identifier.issn1438-7697
dc.identifier.issn1438-9312
dc.identifier.issue12en_US
dc.identifier.scopus2-s2.0-85116866393en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/ejlt.202100102
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7598
dc.identifier.volume123en_US
dc.identifier.wosWOS:000707866800001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofEuropean Journal of Lipid Science and Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectalveolar bone lossen_US
dc.subjectfatty acidsen_US
dc.subjectomega-3en_US
dc.subjectoxidative stressen_US
dc.subjectperiodontitisen_US
dc.titleThe Effects of Omega-3 Supplementation on Serum Oxidative Stress Parameters in Experimental Periodontitis in an Animal Modelen_US
dc.typeArticleen_US

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