The effect of valsartan on left ventricular myocardial functions in hypertensive patients with left ventricular hypertrophy
Yükleniyor...
Dosyalar
Tarih
2012
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Lippincott Williams & Wilkins
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background It has been shown by various diagnostic methodologies that angiotensin receptor blockage reduces left ventricular mass, improves diastolic function and increases contractility in hypertensive left ventricular hypertrophy (LVH). We planned to detect the effect of angiotensin receptor blockage on midwall mechanics and myocardial dynamics in hypertensive patients with LVH. Methods Angiotensin 2 type 1 receptor blocker (valsartan 80-160 mg) was administered to 38 previously untreated hypertensive patients with LVH for 6 months. Left ventricular midwall mechanics and tissue Doppler velocities were measured at baseline and at the end of the study. Results: Mean blood pressure was reduced from 152 +/- 14/92 +/- 8 to 131 +/- 14/83 +/- 9 mmHg (P<0.05). Left ventricular mass index was decreased from 135 +/- 15 to 114 +/- 14 g/m(2) (P<0.001). Midwall fractional shortening was increased from 19.0 +/- 4 to 22.4 +/- 3% (P<0.05). Circumferential end-systolic wall stress was decreased from 131 +/- 44 to 119 +/- 37 X 10(3) dyn/cm(2) (P<0.05). Left ventricular interventricular septal myocardial tissue peak systolic velocity was increased from 6.7 +/- 1 to 8.1 +/- 0.9 cm/s (P<0.001) and lateral wall myocardial tissue peak systolic velocity was increased from 7.5 +/- 1 to 9.0 +/- 1 cm/s (P<0.001), and E/E-m ratio was significantly decreased (11.0 +/- 0.3 to 8.90 +/- 0.1, P<0.05) with 6-month valsartan therapy. Conclusion This study suggests that valsartan exhibits not only blood pressure-lowering qualities but also cardioprotective actions in patients with hypertension because it enhances regression of LVH and improves left ventricular myocardial contractility and relaxation.
Açıklama
Anahtar Kelimeler
angiotensin receptor blocker, hypertension, left ventricular hypertrophy, midwall mechanics, tissue Doppler imaging
Kaynak
Journal of Cardiovascular Medicine
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
13
Sayı
3
