The effect of valsartan on left ventricular myocardial functions in hypertensive patients with left ventricular hypertrophy

Basit Öğe Kaydı
dc.authoridKucukler, Nagehan/0000-0002-9867-266X
dc.authoridKURT, IBRAHIM HALIL/0000-0001-5007-2246
dc.contributor.authorKucukler, Nagehan
dc.contributor.authorKurt, Ibrahim H.
dc.contributor.authorTopaloglu, Caner
dc.contributor.authorGurbuz, Suleyman
dc.contributor.authorYalcin, Fatih
dc.date.accessioned2024-09-18T19:54:22Z
dc.date.available2024-09-18T19:54:22Z
dc.date.issued2012
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground It has been shown by various diagnostic methodologies that angiotensin receptor blockage reduces left ventricular mass, improves diastolic function and increases contractility in hypertensive left ventricular hypertrophy (LVH). We planned to detect the effect of angiotensin receptor blockage on midwall mechanics and myocardial dynamics in hypertensive patients with LVH. Methods Angiotensin 2 type 1 receptor blocker (valsartan 80-160 mg) was administered to 38 previously untreated hypertensive patients with LVH for 6 months. Left ventricular midwall mechanics and tissue Doppler velocities were measured at baseline and at the end of the study. Results: Mean blood pressure was reduced from 152 +/- 14/92 +/- 8 to 131 +/- 14/83 +/- 9 mmHg (P<0.05). Left ventricular mass index was decreased from 135 +/- 15 to 114 +/- 14 g/m(2) (P<0.001). Midwall fractional shortening was increased from 19.0 +/- 4 to 22.4 +/- 3% (P<0.05). Circumferential end-systolic wall stress was decreased from 131 +/- 44 to 119 +/- 37 X 10(3) dyn/cm(2) (P<0.05). Left ventricular interventricular septal myocardial tissue peak systolic velocity was increased from 6.7 +/- 1 to 8.1 +/- 0.9 cm/s (P<0.001) and lateral wall myocardial tissue peak systolic velocity was increased from 7.5 +/- 1 to 9.0 +/- 1 cm/s (P<0.001), and E/E-m ratio was significantly decreased (11.0 +/- 0.3 to 8.90 +/- 0.1, P<0.05) with 6-month valsartan therapy. Conclusion This study suggests that valsartan exhibits not only blood pressure-lowering qualities but also cardioprotective actions in patients with hypertension because it enhances regression of LVH and improves left ventricular myocardial contractility and relaxation.en_US
dc.description.sponsorshipNovartis Pharmaceuticalsen_US
dc.description.sponsorshipF.Y. has received research funding from Novartis Pharmaceuticals. ClinicalTrials.gov identifier: NCT01425411.en_US
dc.identifier.doi10.2459/JCM.0b013e3283511f00
dc.identifier.endpage186en_US
dc.identifier.issn1558-2027
dc.identifier.issue3en_US
dc.identifier.pmid22306782en_US
dc.identifier.scopus2-s2.0-84856443777en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage181en_US
dc.identifier.urihttps://doi.org/10.2459/JCM.0b013e3283511f00
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7690
dc.identifier.volume13en_US
dc.identifier.wosWOS:000300385400003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal of Cardiovascular Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectangiotensin receptor blockeren_US
dc.subjecthypertensionen_US
dc.subjectleft ventricular hypertrophyen_US
dc.subjectmidwall mechanicsen_US
dc.subjecttissue Doppler imagingen_US
dc.titleThe effect of valsartan on left ventricular myocardial functions in hypertensive patients with left ventricular hypertrophyen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ N/A ]
İsim:
7690.pdf
Boyut:
335.67 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu