Ex Vivo Tracheal Mucociliary Clearance in Rats: Comparisons of Nebulization versus Irrigation with Lactated Ringer and Saline Solutions
Yükleniyor...
Dosyalar
Tarih
2009
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Bmc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: This study was performed to compare the effects of isotonic saline, hypertonic saline (buffered/nonbuffered), and lactated Ringer irrigation and distilled water nebulization on mucociliary clearance in ex vivo rats. Design: Experimental study. Setting: Tertiary otolaryngology care centre. Methods: Thirty rat tracheas were achieved from 15 rats by dividing the trachea longitudinally into two equal parts. Main Outcome Measures: Mucociliary transport velocity was measured by direct observation of particle placed on the lower end of the trachea after irrigation or nebulization. Results: Significant improvement in mucociliary clearance was found with isotonic saline (p = .002), buffered hypertonic saline (p = .018), lactated Ringer (p = .000), and nebulized distilled water (p = .000) when compared with nonbuffered hypertonic saline. Conclusion: Lactated Ringer solution is better than saline solution at enhancing mucociliary clearance, but nebulized distilled water is superior to the tested irrigation solutions in rat tracheal epithelium.
Açıklama
Anahtar Kelimeler
irrigation, lactated Ringer solution, mucociliary clearance, nebulization, rat, saline, trachea
Kaynak
Journal of Otolaryngology-Head & Neck Surgery
WoS Q Değeri
Q4
Scopus Q Değeri
Q1
Cilt
38
Sayı
4
