Ex Vivo Tracheal Mucociliary Clearance in Rats: Comparisons of Nebulization versus Irrigation with Lactated Ringer and Saline Solutions

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dc.authoridBabayigit, Cenk/0000-0001-9760-6081
dc.contributor.authorOkuyucu, Semsettin
dc.contributor.authorAkoglu, Ertap
dc.contributor.authorBabayigit, Cenk
dc.contributor.authorAkoglu, Sebahat
dc.contributor.authorDagli, Safak
dc.date.accessioned2024-09-18T20:28:10Z
dc.date.available2024-09-18T20:28:10Z
dc.date.issued2009
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: This study was performed to compare the effects of isotonic saline, hypertonic saline (buffered/nonbuffered), and lactated Ringer irrigation and distilled water nebulization on mucociliary clearance in ex vivo rats. Design: Experimental study. Setting: Tertiary otolaryngology care centre. Methods: Thirty rat tracheas were achieved from 15 rats by dividing the trachea longitudinally into two equal parts. Main Outcome Measures: Mucociliary transport velocity was measured by direct observation of particle placed on the lower end of the trachea after irrigation or nebulization. Results: Significant improvement in mucociliary clearance was found with isotonic saline (p = .002), buffered hypertonic saline (p = .018), lactated Ringer (p = .000), and nebulized distilled water (p = .000) when compared with nonbuffered hypertonic saline. Conclusion: Lactated Ringer solution is better than saline solution at enhancing mucociliary clearance, but nebulized distilled water is superior to the tested irrigation solutions in rat tracheal epithelium.en_US
dc.identifier.doi10.2310/7070.2009.080193
dc.identifier.endpage426en_US
dc.identifier.issn1916-0216
dc.identifier.issue4en_US
dc.identifier.pmid19755081en_US
dc.identifier.scopus2-s2.0-70349243237en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage422en_US
dc.identifier.urihttps://doi.org/10.2310/7070.2009.080193
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10773
dc.identifier.volume38en_US
dc.identifier.wosWOS:000273634500002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBmcen_US
dc.relation.ispartofJournal of Otolaryngology-Head & Neck Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectirrigationen_US
dc.subjectlactated Ringer solutionen_US
dc.subjectmucociliary clearanceen_US
dc.subjectnebulizationen_US
dc.subjectraten_US
dc.subjectsalineen_US
dc.subjecttracheaen_US
dc.titleEx Vivo Tracheal Mucociliary Clearance in Rats: Comparisons of Nebulization versus Irrigation with Lactated Ringer and Saline Solutionsen_US
dc.typeArticleen_US

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