Renal Angiomyolipoma: A Clinicopathological Study of Seven Cases and Review of the Literature

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dc.authoridSecinti, Ilke Evrim/0000-0002-8614-3971
dc.authoridGORUR, Sadik/0000-0002-3458-5428
dc.contributor.authorGursoy, Didar
dc.contributor.authorSecinti, Ilke Evrim
dc.contributor.authorHakverdi, Sibel
dc.contributor.authorGorur, Sadik
dc.date.accessioned2024-09-18T20:11:30Z
dc.date.available2024-09-18T20:11:30Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: Renal angiomyolipomas (AMLs) are mesenchymal kidney tumours that have triphasic histology. This study aimed to present the clinical, pathological and immunohistochemical features of seven AML cases along with a review of the relevant literature. Materials and Methods: Seven cases of pathologically diagnosed AML were included in the study. The presence of fat tissues, smooth muscle cells, blood vessels and epithelioid components were determined for all cases. Tumour necrosis, haemorrhage, mitosis, lymphovascular and perineural invasion were also recorded. Immune markers [human melanoma black-45 (HMB45), Melan-A, smooth muscle actin (SMA), cytokeratin], previously applied to the tissue sections, were reevaluated as positive and negative staining. Results: All cases were classic AML types. Five patients had flank pain and two had haematuria. The tumour was located in the left kidney in two cases and in the right kidney in five cases. The mean size of the AMLs was 7.36 +/- 4.23 cm. Tumours were separated from the normal kidney parenchyma with good margins and composed of mature fatty tissues, blood vessels and fusiform spindle smooth muscle cells in varying proportions. Immunohistochemically, all cases were positive with HMB-45, Melan-A and SMA. No case was positive for cytokeratin staining. Conclusion: Correct histological diagnosis of renal AML subtypes is crucial. Incorrect diagnosis of classic renal AML may lead to inadequate postoperative management. Clinicians should be aware of the malignant potential of epithelioid AML and the need for long-term follow-up.en_US
dc.identifier.doi10.4274/uob.galenos.2020.1438
dc.identifier.endpage123en_US
dc.identifier.issn2147-2270
dc.identifier.issue3en_US
dc.identifier.startpage118en_US
dc.identifier.trdizinid366367en_US
dc.identifier.urihttps://doi.org/10.4274/uob.galenos.2020.1438
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/366367
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8908
dc.identifier.volume19en_US
dc.identifier.wosWOS:000562705900006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofUroonkoloji Bulteni-Bulletin of Urooncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectClinicopathological featuresen_US
dc.subjectimmunohistochemistryen_US
dc.subjectrenal angiomyolipomaen_US
dc.titleRenal Angiomyolipoma: A Clinicopathological Study of Seven Cases and Review of the Literatureen_US
dc.typeReview Articleen_US

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