Effect of serum adropin levels on circulating endothelial dysfunction biomarkers in COVID-19 patients

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dc.authoridErdogan, Haluk/0000-0002-9033-4236
dc.contributor.authorGunesacar, Ramazan
dc.contributor.authorEksi, Durkadin Demir
dc.contributor.authorAlpay, Ali Seydi
dc.contributor.authorHanikoglu, Ferhat
dc.contributor.authorErdogan, Haluk
dc.date.accessioned2024-09-18T20:13:26Z
dc.date.available2024-09-18T20:13:26Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPurpose: Several studies show that the symptoms of severe COVID-19 infection reflect the clinical phenotype of endothelial dysfunction and share common pathophysiological mechanisms with endothelial dysfunction. Therefore, the aim of the study was to investigate the effect of serum adropin levels on endothelial dysfunction biomarkers and determine whether adropin could be a new biomarker for COVID-19.Materials and Methods: The study included 40 patients with mild/moderate COVID-19, 48 patients with severe/critical COVID-19, and 37 controls. Serum adropin and circulating biomarkers of endothelial dysfunction including asymmetric dimethylarginine (ADMA), endothelin-1 (ET-1), endothelial nitric oxide synthase (eNOS), soluble intercellular adhesion molecule-1 (sICAM-1) and plasminogen activator inhibitor-1 (PAI-1) levels were determined by micro-ELISA. Results: Serum adropin levels were found to be significantly higher in COVID-19 patients (165.2 & PLUSMN;11.49 pg/ml) than in controls (85.46 & PLUSMN;12.08 pg/ml). Serum adropin levels of patients with severe/critical symptoms (194 & PLUSMN;16.23 pg/ml) were significantly higher than the patients with mild/moderate symptoms (130.6 & PLUSMN;14.53). In addition, serum ADMA, eNOS, and, ET-1 levels were significantly higher in the COVID-19 subjects (150.5 & PLUSMN;8.67 ng/ml, 172.4 & PLUSMN;14.01 pg/ml, 159.3 & PLUSMN;10.19 pg/ml, respectively) than that those in the controls (104.5 & PLUSMN;9.182 ng/ml, 141.4 & PLUSMN;17.74 pg/ml, 100.1 & PLUSMN;11.37 pg/ml, respectively). Significant positive correlations were found between adropin and ADMA, eNOS, ET-1, sICAM-1, and PAI-1 levels in the patients. Conclusion: We suggest that adropin may be a new potential biomarker for COVID-19 and an important molecule in restoring endothelial cell damage. Positive correlations between serum adropin levels and ADMA, eNOS, ET-1, sICAM-1 and PAI-1 levels in patients suggest that adropin may compensate for damage to endothelial cells.en_US
dc.description.sponsorshipAlanya Alaaddin Keykubat University Research Fund, Antalya, Turkiye [2021-04-01-MAP13]en_US
dc.description.sponsorship& nbsp;This study was supported by the Alanya Alaaddin Keykubat University Research Fund, Antalya, Turkiye (Project number: 2021-04-01-MAP13) .en_US
dc.identifier.doi10.17826/cumj.1279322
dc.identifier.endpage574en_US
dc.identifier.issn2602-3032
dc.identifier.issn2602-3040
dc.identifier.issue2en_US
dc.identifier.startpage567en_US
dc.identifier.trdizinid1197746en_US
dc.identifier.urihttps://doi.org/10.17826/cumj.1279322
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1197746
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9184
dc.identifier.volume48en_US
dc.identifier.wosWOS:001038321300028en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherCukurova Univ, Fac Medicineen_US
dc.relation.ispartofCukurova Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCOVID-19en_US
dc.subjectadropinen_US
dc.subjectendothelial dysfunctionen_US
dc.subjectbiomarkersen_US
dc.titleEffect of serum adropin levels on circulating endothelial dysfunction biomarkers in COVID-19 patientsen_US
dc.typeArticleen_US

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