Effects of high dose lead toxication on liver, kidneyse, heart, brain and blood in rabbits : An experimental study

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dc.contributor.authorDurgut, Ramazan
dc.contributor.authorKoç, Ahmet
dc.contributor.authorGönenci, Ramazan
dc.contributor.authorBal, Ramazan
dc.contributor.authorÇelik, Sefa
dc.contributor.authorGüzel, Murat
dc.contributor.authorAltuğ, Muhammed Enes
dc.contributor.authorAteşoğlu, Emine Özlem
dc.date.accessioned2019-07-16T15:48:29Z
dc.date.available2019-07-16T15:48:29Z
dc.date.issued2008
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe aim of the study was to investigate effects of high dose lead (Pb) exposure on heart, blood, kidney, liver and brain in rabbits using clinical, electrocardiographical (ECG), ultrasonographical, haematological, biochemical and pathological methods. The experiments were performed on 15 male New Zealand rabbits, divided into three equal groups and were orally given 80 ppm or 160 ppm Pb for 15 days and the other group was used as control. Administration of 80 or 160 ppm lead signifi cantly increased the activities of serum aspartate aminotransferase (AST), alanin aminotransferase (ALT), lactate dehydrogenase (LDH), creatine phosphokinase (CPK) and alkaline phosphatase (ALP). Hemoglobin (HB) and hematocrit (HCT) values were signifi cantly lower in 80 and 160 ppm Pb-treated animals compared to the control animals (p<0.001). QRS complexes were wider and amplitudes of T wave were larger in treatment groups compared to contro group (p<0.05). Severe hydropic and vacuoler degenerations were seen in hepatocytes and vacuolation and degeneration of proximal tubular epithelial cells in cortex in the treatment groups histopathologically. Some neurons were severely degenerated, and severe neuron necroses were seen in cornu ammonis of both of the treatment groups. Severe mononuclear cell infi ltrations were observed in Wirchow-Robin spaces. In conclusion, deleterious effects observed in liver, kidney and blood in high doses of lead administration with some similarities to chronic oral administration of low doses.en_US
dc.description.abstracten_US
dc.identifier.endpage18en_US
dc.identifier.issn1307-1130
dc.identifier.issue2en_US
dc.identifier.startpage11en_US
dc.identifier.urihttps://trdizin.gov.tr/publication/paper/detail/TnpreE1UTXo=
dc.identifier.urihttps://hdl.handle.net/20.500.12483/1058
dc.identifier.volume2en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Applied Biological Sciencesen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBiyolojien_US
dc.titleEffects of high dose lead toxication on liver, kidneyse, heart, brain and blood in rabbits : An experimental studyen_US
dc.typeArticleen_US

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