The Relationship Between Duration of Hemodialysis, Helicobacter pylori and CagA Seropositivity in Patients with Chronic Kidney Disease

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dc.authoridozcan, oguzhan/0000-0001-7486-503X
dc.authoridErdal, Huseyin/0000-0003-0786-5077
dc.authoridTURGUT, FARUK/0000-0003-1910-7433
dc.contributor.authorOzcan, Oguzhan
dc.contributor.authorErdal, Huseyin
dc.contributor.authorOzer, Burcin
dc.contributor.authorKacmaz, Filiz
dc.contributor.authorTurgut, Faruk
dc.date.accessioned2024-09-18T20:26:32Z
dc.date.available2024-09-18T20:26:32Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIntroduction: The aim of this study was to investigate the relationship between Helicobacter pylori occurrence and, Cytotoxin-associated gene A (CagA) seropositivity with hemodialysis (HD) duration, Serum C-reactive protein (CRP) and hemogram parameters in hemodialysis patients. Materials and Methods: This study included 165 prevalent HD patients. Blood samples were collected before dialysis treatment of the patients. The samples were then centrifuged at 1500 x g for 10 min. immediately after collection. The presence of serum IgG antibody for H. pylori was determined using commercial ELISA kits. Serum anti-CagA IgG antibody of H. pylori positive patients was determined by ELISA method using commercial ELISA kits. CRP levels were measured by nephelometric method, and hemogram parameters were analyzed using fully automated hematology analyzer. Results: We found that the CRP levels of the patients having H. pylori were significantly high. However, there was no significant difference between CRP levels of long-term hemodialysis (LTHD) and short -term hemodialysis (STHD) patients. The possibility of being seropositive of CagA for STHD patients having H. pylori was found to be 2.3 times higher than that of LTHD patients. In addition to that, the periodicity of gastrointestinal (GI) bleeding was significantly high in STHD patients. Conclusion: In conclusion, we found no relationship between dialysis duration and H. pylori prevalence. However, we observed significantly higher odds ratio for CagA seropositivity in patients receiving STHD. These findings suggest that longer dialysis treatment can cause improving effects on H. pylori virulence. Further studies are needed to verify these findings.en_US
dc.identifier.doi10.5578/flora.69568
dc.identifier.endpage390en_US
dc.identifier.issn1300-932X
dc.identifier.issue3en_US
dc.identifier.startpage383en_US
dc.identifier.trdizinid452306en_US
dc.identifier.urihttps://doi.org/10.5578/flora.69568
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/452306
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10377
dc.identifier.volume25en_US
dc.identifier.wosWOS:000582249100013en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherBilimsel Tip Yayinevien_US
dc.relation.ispartofFlora Infeksiyon Hastaliklari Ve Klinik Mikrobiyoloji Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectH. pylorien_US
dc.subjectHemodialysisen_US
dc.subjectCagAen_US
dc.titleThe Relationship Between Duration of Hemodialysis, Helicobacter pylori and CagA Seropositivity in Patients with Chronic Kidney Diseaseen_US
dc.typeArticleen_US

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