Lipid profile and atherogenic indices and their association with platelet indices in familial Mediterranean fever
[ N/A ]
Tarih
2018
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkish Soc Cardiology
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: The aim of this study was to investigate lipid profiles and atherogenic indices and their association with platelet indices in Familial Mediterranean Fever (FMF) patients. Methods: A total of 63 FMF patients and 51 healthy individuals were included in this retrospective study. Inflammatory marker values (erythrocyte sedimentation rate [ESR], C-reactive protein [CRP] and fibrinogen), platelet indices (mean platelet volume, plateletcrit value, platelet large cell ratio, and platelet distribution width), lipid profiles (levels of total cholesterol, triglycerides, high-density lipoprotein [HDL] cholesterol, and low-density lipoprotein cholesterol) were recorded. Atherogenic indices (atherogenic index of plasma [AIP], atherogenic coefficient [AC], Castelli's risk indices I and II [CRI I and II]) were calculated using lipid parameters. Results: In FMF patients, while AIP, AC, and CRI I and II values were significantly higher than in the healthy control group, the HDL cholesterol level was significantly lower (all p<0.05). However, no significant difference was determined in terms of the other studied parameters (all p>0.05). In male FMF patients, whereas AIP, AC, and CRI I and II values were significantly higher than in female FMF patients, the platelet count, ESR, and HDL cholesterol levels were significantly lower (all p<0.05). The level of CRP was negatively correlated with HDL cholesterol (r=-0.275; p=0.032) and total cholesterol level (r=-0.313; p=0.014) in FMF patients. HDL cholesterol level was negatively correlated with disease duration (r=-0.269; p=0.049). Conclusion: The use of atherogenic indices may be recommended to identify patients with an increased risk of atherosclerotic cardiovascular disease in FMF, especially in male patients.
Açıklama
Anahtar Kelimeler
High-Density-Lipoprotein, Coronary-Artery-Disease, Subclinical Inflammation, Cardiovascular-Disease, Myocardial-Infarction, Heart-Disease, Cholesterol, Atherosclerosis, Colchicine, Volume
Kaynak
Turk Kardiyoloji Dernegi Arsivi-Archives of The Turkish Society of Cardiology
WoS Q Değeri
N/A
Scopus Q Değeri
Q3
Cilt
46
Sayı
3
