Lipid profile and atherogenic indices and their association with platelet indices in familial Mediterranean fever

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dc.contributor.authorCakirca, Gokhan
dc.contributor.authorCelik, Muhammet Murat
dc.date.accessioned2024-09-18T21:06:43Z
dc.date.available2024-09-18T21:06:43Z
dc.date.issued2018
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: The aim of this study was to investigate lipid profiles and atherogenic indices and their association with platelet indices in Familial Mediterranean Fever (FMF) patients. Methods: A total of 63 FMF patients and 51 healthy individuals were included in this retrospective study. Inflammatory marker values (erythrocyte sedimentation rate [ESR], C-reactive protein [CRP] and fibrinogen), platelet indices (mean platelet volume, plateletcrit value, platelet large cell ratio, and platelet distribution width), lipid profiles (levels of total cholesterol, triglycerides, high-density lipoprotein [HDL] cholesterol, and low-density lipoprotein cholesterol) were recorded. Atherogenic indices (atherogenic index of plasma [AIP], atherogenic coefficient [AC], Castelli's risk indices I and II [CRI I and II]) were calculated using lipid parameters. Results: In FMF patients, while AIP, AC, and CRI I and II values were significantly higher than in the healthy control group, the HDL cholesterol level was significantly lower (all p<0.05). However, no significant difference was determined in terms of the other studied parameters (all p>0.05). In male FMF patients, whereas AIP, AC, and CRI I and II values were significantly higher than in female FMF patients, the platelet count, ESR, and HDL cholesterol levels were significantly lower (all p<0.05). The level of CRP was negatively correlated with HDL cholesterol (r=-0.275; p=0.032) and total cholesterol level (r=-0.313; p=0.014) in FMF patients. HDL cholesterol level was negatively correlated with disease duration (r=-0.269; p=0.049). Conclusion: The use of atherogenic indices may be recommended to identify patients with an increased risk of atherosclerotic cardiovascular disease in FMF, especially in male patients.en_US
dc.identifier.doi10.5543/tkda.2018.93762
dc.identifier.endpage190en_US
dc.identifier.issn1016-5169
dc.identifier.issue3en_US
dc.identifier.pmid29664424en_US
dc.identifier.scopus2-s2.0-85045520657en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage184en_US
dc.identifier.urihttps://doi.org/10.5543/tkda.2018.93762
dc.identifier.urihttps://hdl.handle.net/20.500.12483/13779
dc.identifier.volume46en_US
dc.identifier.wosWOS:000435147300003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Soc Cardiologyen_US
dc.relation.ispartofTurk Kardiyoloji Dernegi Arsivi-Archives of The Turkish Society of Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHigh-Density-Lipoproteinen_US
dc.subjectCoronary-Artery-Diseaseen_US
dc.subjectSubclinical Inflammationen_US
dc.subjectCardiovascular-Diseaseen_US
dc.subjectMyocardial-Infarctionen_US
dc.subjectHeart-Diseaseen_US
dc.subjectCholesterolen_US
dc.subjectAtherosclerosisen_US
dc.subjectColchicineen_US
dc.subjectVolumeen_US
dc.titleLipid profile and atherogenic indices and their association with platelet indices in familial Mediterranean feveren_US
dc.typeArticleen_US

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