Quantification of MMP-2 and TIMP-1 expressions in breast cancer

Basit Öğe Kaydı
dc.contributor.authorKeskin, Seda Eren
dc.contributor.authorAkkoyunlu, Deniz Sunnetci
dc.contributor.authorTezcan, Mehtap Yilmaz
dc.contributor.authorSimsek, Turgay
dc.contributor.authorGuler, Sertac Ata
dc.contributor.authorCine, Naci
dc.contributor.authorCanturk, Nuh Zafer
dc.date.accessioned2024-09-18T20:06:12Z
dc.date.available2024-09-18T20:06:12Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground and Aims: MMP-2 and TIMP-1 are vital molecules in the remodeling of the extracellular matrix, and they have a critical role in the metastatic process of breast cancer. This study aimed to detect expression levels of MMP-2 and TIMP-1 genes by Quantitative Real-Time Polymerase Chain Reaction (qRT-PCR) and identify their potential roles in breast cancer prognosis. Methods: MMP-2 and TIMP-1 gene expression levels in 17 breast cancer tumor tissues and normal breast tissue were examined. The expression levels of MMP-2 and TIMP-1 were analyzed by qRT-PCR. The association between the expression levels of MMP-2 and TIMP-1 and clinicopathological manifestations of breast cancer was examined. Results: Lower gene expression levels of MMP-2 and TIMP-1 were detected in tumors compared to the controls. A statistical correlation was not observed between the expression level of MMP-2, TIMP-1, and clinicopathological parameters (tumor Conclusion: Our findings have been suggesting that expression profiles of MMP-2 and TIMP-1 might be independent prognostic and predictive biomarkers for breast cancer. These biomarkers are candidate molecules for personalized therapy. MMP-2 and TIMP-1 expression patterns will also aid in the identification of more precise and targeted subgroups of breast cancer.en_US
dc.description.sponsorshipKocaeli University BAP [2009/022]en_US
dc.description.sponsorshipThis study was supported by Kocaeli University BAP (Project Number; 2009/022) .en_US
dc.identifier.doi10.26650/IstanbulJPharm.2023.1053089
dc.identifier.endpage218en_US
dc.identifier.issn2587-2087
dc.identifier.issue2en_US
dc.identifier.startpage211en_US
dc.identifier.trdizinid1240208en_US
dc.identifier.urihttps://doi.org/10.26650/IstanbulJPharm.2023.1053089
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1240208
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8369
dc.identifier.volume53en_US
dc.identifier.wosWOS:001110261800012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherIstanbul Univ, Fac Pharmacyen_US
dc.relation.ispartofIstanbul Journal of Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBreast canceren_US
dc.subjectMMP2 metalloproteinaseen_US
dc.subjectTIMP-1en_US
dc.titleQuantification of MMP-2 and TIMP-1 expressions in breast canceren_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Tam Metin / Full text
Boyut:
324.85 KB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu