Nicotine metabolism and its biologic effects
[ N/A ]
Tarih
2003
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Nicotine is a naturally occuring alkaloid found in many plants. The principal sources of nicotine exposure is through the use of tobacco, nicotine containing gum and nicotine replacement therapies. Nicotine is an amine composed of pyridine and pyrrolidine rings. It has been shown that nicotine crosses biological membranes and the blood brain barrier easily. The absorbed nicotine is extensively metabolised in the liver to form a wide variety of metabolites including nicotine N'-oxide and cotinine N'-oxide. These are the products of mixed function oxidase system. Nicotine is also converted to some biologically important compounds during harvesting. Among these are the nitrosamines specific to tobacco. Nicotine has been shown to affect a wide variety of biological functions ranging from gene expression, regulation of hormone secretion and enzyme activities.
Açıklama
Anahtar Kelimeler
alkaloid, amine, cotinine n' oxide, drug metabolite, hormone, nicotine, nicotine gum, nicotine n' oxide, oxidoreductase, pyridine, pyrrolidine derivative, unclassified drug, article, blood brain barrier, cigarette smoking, drug metabolism, drug transport, enzyme activity, gene expression, harvest, hormone release, human, liver metabolism, membrane transport, nicotine replacement therapy, regulatory mechanism, tobacco
Kaynak
SENDROM
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
15
Sayı
1
