Nicotine metabolism and its biologic effects

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dc.authorscopusid6701518475
dc.contributor.authorYildiz, Deniz
dc.date.accessioned2024-09-19T15:49:50Z
dc.date.available2024-09-19T15:49:50Z
dc.date.issued2003
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractNicotine is a naturally occuring alkaloid found in many plants. The principal sources of nicotine exposure is through the use of tobacco, nicotine containing gum and nicotine replacement therapies. Nicotine is an amine composed of pyridine and pyrrolidine rings. It has been shown that nicotine crosses biological membranes and the blood brain barrier easily. The absorbed nicotine is extensively metabolised in the liver to form a wide variety of metabolites including nicotine N'-oxide and cotinine N'-oxide. These are the products of mixed function oxidase system. Nicotine is also converted to some biologically important compounds during harvesting. Among these are the nitrosamines specific to tobacco. Nicotine has been shown to affect a wide variety of biological functions ranging from gene expression, regulation of hormone secretion and enzyme activities.en_US
dc.identifier.endpage82en_US
dc.identifier.issn1016-5134
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-0037221889en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage78en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/15438
dc.identifier.volume15en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofSENDROMen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectalkaloiden_US
dc.subjectamineen_US
dc.subjectcotinine n' oxideen_US
dc.subjectdrug metaboliteen_US
dc.subjecthormoneen_US
dc.subjectnicotineen_US
dc.subjectnicotine gumen_US
dc.subjectnicotine n' oxideen_US
dc.subjectoxidoreductaseen_US
dc.subjectpyridineen_US
dc.subjectpyrrolidine derivativeen_US
dc.subjectunclassified drugen_US
dc.subjectarticleen_US
dc.subjectblood brain barrieren_US
dc.subjectcigarette smokingen_US
dc.subjectdrug metabolismen_US
dc.subjectdrug transporten_US
dc.subjectenzyme activityen_US
dc.subjectgene expressionen_US
dc.subjectharvesten_US
dc.subjecthormone releaseen_US
dc.subjecthumanen_US
dc.subjectliver metabolismen_US
dc.subjectmembrane transporten_US
dc.subjectnicotine replacement therapyen_US
dc.subjectregulatory mechanismen_US
dc.subjecttobaccoen_US
dc.titleNicotine metabolism and its biologic effectsen_US
dc.title.alternativeNikotin metabolizmasi ve biyolojik etkilerien_US
dc.typeArticleen_US

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