Serum matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1 and matrix metalloproteinase-9/ neutrophil gelatinase-associated lipocalin complex levels in patients with early-stage diabetic nephropathy
[ N/A ]
Tarih
2018
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Iranian Society of Nephrology
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Introduction. This study was aimed to investigate the efficacy of matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1), and the neutrophil gelatinase-associated lipocalin (NGAL)-bound form of MMP-9 (MMP-9/NGAL complex) markers in the determination of early nephropathy in patients with type 2 diabetes mellitus. Materials and Methods. Twenty-five type 2 diabetic patients with normoalbuminuria, 27 type 2 diabetic patients with microalbuminuria, and 23 healthy controls were recruited. Serum levels of MMP-9, TIMP-1, and MMP9/NGAL complex were measured in all participants. Results. The MMP-9 level and MMP-9/TIMP-1 ratio were higher in patients with microalbuminuria when compared to the controls, while TIMP-1 level was lower (P =.005, P =.006, and P =.02, respectively). The MMP-9 level and MMP-9/TIMP-1 ratio were significantly higher in the patients with normoalbuminuria when compared to the controls (P =.005 and P =.02, respectively). In the normoalbuminuric patients, MMP-9 levels were negatively correlated with estimated GFR (r =-0.553, P =.008) and positively correlated with glucose (r = 0.449, P =.04), creatinine (r = 0.454, P =.03), and MMP9/NGAL complex (r = 0.575, P =.005). In the microalbuminuric patients, MMP-9 levels were positively correlated with total cholesterol (r = 0.430, P =.03), and MMP9/NGAL complex (r = 0.650, P =.001). Conclusions. The levels of MMP-9, TIMP-1, and MMP9/NGAL complex were similar in microalbuminuric and normoalbuminuric patients with type 2 diabetes mellitus. However, there was a significant MMP-9/TIMP-1 imbalance in both groups which may reflect impaired extracellular matrix homeostasis. © 2018, Iranian Society of Nephrology. All rights reserved.
Açıklama
Anahtar Kelimeler
Diabetic nephropathy, Extracellular matrix, Matrix metalloproteinase-9, MMP-9/NGAL complex, Tissue inhibitor-1
Kaynak
Iranian Journal of Kidney Diseases
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
12
Sayı
5
