Serum matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1 and matrix metalloproteinase-9/ neutrophil gelatinase-associated lipocalin complex levels in patients with early-stage diabetic nephropathy

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dc.authorscopusid56112957200
dc.authorscopusid15137254500
dc.contributor.authorCakirca, Gokhan
dc.contributor.authorTurgut, Faruk Hilmi
dc.date.accessioned2024-09-19T15:47:02Z
dc.date.available2024-09-19T15:47:02Z
dc.date.issued2018
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIntroduction. This study was aimed to investigate the efficacy of matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1), and the neutrophil gelatinase-associated lipocalin (NGAL)-bound form of MMP-9 (MMP-9/NGAL complex) markers in the determination of early nephropathy in patients with type 2 diabetes mellitus. Materials and Methods. Twenty-five type 2 diabetic patients with normoalbuminuria, 27 type 2 diabetic patients with microalbuminuria, and 23 healthy controls were recruited. Serum levels of MMP-9, TIMP-1, and MMP9/NGAL complex were measured in all participants. Results. The MMP-9 level and MMP-9/TIMP-1 ratio were higher in patients with microalbuminuria when compared to the controls, while TIMP-1 level was lower (P =.005, P =.006, and P =.02, respectively). The MMP-9 level and MMP-9/TIMP-1 ratio were significantly higher in the patients with normoalbuminuria when compared to the controls (P =.005 and P =.02, respectively). In the normoalbuminuric patients, MMP-9 levels were negatively correlated with estimated GFR (r =-0.553, P =.008) and positively correlated with glucose (r = 0.449, P =.04), creatinine (r = 0.454, P =.03), and MMP9/NGAL complex (r = 0.575, P =.005). In the microalbuminuric patients, MMP-9 levels were positively correlated with total cholesterol (r = 0.430, P =.03), and MMP9/NGAL complex (r = 0.650, P =.001). Conclusions. The levels of MMP-9, TIMP-1, and MMP9/NGAL complex were similar in microalbuminuric and normoalbuminuric patients with type 2 diabetes mellitus. However, there was a significant MMP-9/TIMP-1 imbalance in both groups which may reflect impaired extracellular matrix homeostasis. © 2018, Iranian Society of Nephrology. All rights reserved.en_US
dc.description.sponsorshipCoordination Office of Scientific Research Projects in Mustafa Kemal University, (15437); Mustafa Kemal Üniversitesi, MKUen_US
dc.identifier.endpage304en_US
dc.identifier.issn1735-8582
dc.identifier.issue5en_US
dc.identifier.pmid30367022en_US
dc.identifier.scopus2-s2.0-85055617162en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage299en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14924
dc.identifier.volume12en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherIranian Society of Nephrologyen_US
dc.relation.ispartofIranian Journal of Kidney Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetic nephropathyen_US
dc.subjectExtracellular matrixen_US
dc.subjectMatrix metalloproteinase-9en_US
dc.subjectMMP-9/NGAL complexen_US
dc.subjectTissue inhibitor-1en_US
dc.titleSerum matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1 and matrix metalloproteinase-9/ neutrophil gelatinase-associated lipocalin complex levels in patients with early-stage diabetic nephropathyen_US
dc.typeArticleen_US

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