Investigation of Toxin Profiles of Methicillin Resistant and Sensitive Staphylococcus aureus Strains Isolated from Various Clinical Specimens

Basit Öğe Kaydı
dc.contributor.authorBayırlı, Mücella
dc.contributor.authorAslantaş, Özkan
dc.contributor.authorÖzer, Burçin
dc.date.accessioned2024-09-19T16:22:13Z
dc.date.available2024-09-19T16:22:13Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAim: This study aimed to investigate the superantigenic (SAg) toxin, exfoliative toxin (ET), hemolysin (HLY), leukotoxin (LUK) genes and accessory gene regulator (agr) types in Staphylococcus aureus isolates from various clinical materials. Material and Methods: A total of 190 S. aureus isolates were investigated for the presence of toxin genes, mecA gene and agr types using by polymerase chain reaction (PCR). Results: mecA gene was detected in 87 (45.8%) isolates. Of the 190 S. aureus isolates examined, 83.7% (n=159) were found to be positive for SAg genes. The seg (41.1%) was determinedtobethemostcommontoxingene,followedbysei(38.9%),selo(38.9%), selm (28.4%), sea (%25.8), and tst (18.4%) genes, respectively. Seventy one different SAg toxin profiles were identified. Type I ?Sa? encoding seg, sei, selm, seln and selo was the most commonmobilegeneticelement(MGE),whichwasdetectedin37isolates(19.5%). Thehla,hlb,hld,hlgandhlg2genesweredetectedin92.6%(n=176),1.6%(n=3), 98.9% (n=188), 1.1% (n=2) and 31.6% (n=60) of the isolates, respectively. The pvl gene was detected in 12.6% (n=11) of methicillin resistant S. aureus (MRSA) and 14.6% (n=15) of methicillin sensitive S. aureus (MSSA), respectively (p=0.701). While none of the isolates carried lukM gene, 67% (n=69) of MSSA and 69% (n=60) of MRSA isolates were found to be positive for lukED gene (p=0.519). Conclusion: High occurrence and diversity of toxin genes among S. aureus isolates could be explained by horizontal transmission of toxin genes through MGEs.en_US
dc.identifier.doi10.18678/dtfd.956666
dc.identifier.endpage251en_US
dc.identifier.issn1307-671X
dc.identifier.issue3en_US
dc.identifier.startpage244en_US
dc.identifier.trdizinid495748en_US
dc.identifier.urihttps://doi.org/10.18678/dtfd.956666
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/495748
dc.identifier.urihttps://hdl.handle.net/20.500.12483/15709
dc.identifier.volume23en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofDüzce Tıp Fakültesi Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectStaphylococcus aureusen_US
dc.titleInvestigation of Toxin Profiles of Methicillin Resistant and Sensitive Staphylococcus aureus Strains Isolated from Various Clinical Specimensen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
15709.pdf
Boyut:
495.57 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu