Readily Accessible and Brightly Fluorogenic BODIPY/NBD-Tetrazines via SNAr Reactions

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dc.authoridIsik, Murat/0000-0001-5105-906X
dc.contributor.authorIsik, Murat
dc.contributor.authorKisacam, Mehmet Ali
dc.date.accessioned2024-09-18T21:03:15Z
dc.date.available2024-09-18T21:03:15Z
dc.date.issued2024
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractWe describe SNAr reactions of some commercial amino-tetrazines and halo-dyes, which give efficiently quenched BODIPY/NBD-tetrazines (Phi(Fl) < 0.01) in high yields and, importantly, with high purities affordable via simple silica gel chromatography only. The dyes exhibit large Stokes shifts, moderate environmental sensitivity, and emission enhancements (up to 193-fold) upon Tz ligation with BCN & horbar;a strained dienophile. They successfully serve as labels for HSA protein premodified with BCN, resulting in bright blue-green emission upon ligation.en_US
dc.description.sponsorshipT?rkiye Bilimsel ve Teknolojik Arastirma Kurumu [118Z423]; Scientific and Technological Research Council of Turkiye (TUBITAK)en_US
dc.description.sponsorshipThe authors gratefully acknowledge financial support from the Scientific and Technological Research Council of Turkiye (TUBITAK)ygrant number 118Z423.en_US
dc.identifier.doi10.1021/acs.joc.3c02864
dc.identifier.endpage6519en_US
dc.identifier.issn0022-3263
dc.identifier.issn1520-6904
dc.identifier.issue9en_US
dc.identifier.pmid38598957en_US
dc.identifier.scopus2-s2.0-85190117842en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage6513en_US
dc.identifier.urihttps://doi.org/10.1021/acs.joc.3c02864
dc.identifier.urihttps://hdl.handle.net/20.500.12483/13326
dc.identifier.volume89en_US
dc.identifier.wosWOS:001201314100001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmer Chemical Socen_US
dc.relation.ispartofJournal of Organic Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBioorthogonal Reactionsen_US
dc.subjectSmall Moleculesen_US
dc.subjectLive Cellsen_US
dc.subjectProbesen_US
dc.subjectCycloadditionen_US
dc.subjectDyesen_US
dc.subjectDesignen_US
dc.subject1,2,4,5-Tetrazinesen_US
dc.subjectBicyclononynesen_US
dc.subjectDerivativesen_US
dc.titleReadily Accessible and Brightly Fluorogenic BODIPY/NBD-Tetrazines via SNAr Reactionsen_US
dc.typeArticleen_US

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