The comparison of the mrna expressions of tgf?1, bfgf, ıgf-1, ngf and matrix metalloprotease iii genes in cervical and lumbar disc tissues

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dc.contributor.authorYücetaş, Seyho Cem
dc.contributor.authorYılmaz, Atilla
dc.contributor.authorGüleç, Elif
dc.contributor.authorÖziç, Cem
dc.date.accessioned2019-07-16T16:02:05Z
dc.date.available2019-07-16T16:02:05Z
dc.date.issued2018
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAim: To evaluate and compare the mRNA expression of antioxidant genes between the cervical and lumbar degenerated disc tissues. Material and Methods: Obtained degenerated Nucleus Pulposus (DNP) materials were divided into two groups, which were cervical DNP (Group I) (n=20) and lumbar DNP (Group II) (n=20). There are 6 men and 14 women in group I with a mean age of 43.8 years and 13 men and 7 women in group II with the mean age of 40.3 years (28 to 54). All cervical DNP materials were obtained between C5 and C6 and all lumbar DNP materials were obtained between L4 and L5 levels. The TGF?1, bFGF, IGF-1, NGF and Matrix metalloprotease III (MMP III) gene expressions of DNP materials were determined by polymerase chain reaction, Real-time polymerase chain reaction and western blotting techniques.Results: When the results of the two groups were compared by polymerase chain reaction, the expressions of TGF?1, bFGF, IGF-1, NGF and MMP III was found lower in lumbar DNP group. Also the TGF?1, bFGF, IGF-1, NGF, and Matrix metalloprotease III genes showed a decrease in gene expression levels when they were analyzed by Real-time polymerase chain reaction. Conclusion: These data showed that; decrease of the TGF?1, bFGF, IGF-1, NGF and MMP III genes in the degenerated lumbar disc tissues, may related with the possibility of molecular background of the disease pathogenesis.en_US
dc.identifier.endpage95en_US
dc.identifier.issn1300-1744
dc.identifier.issue1en_US
dc.identifier.startpage92en_US
dc.identifier.urihttps://trdizin.gov.tr/publication/paper/detail/TWpnMU16ZzVPUT09
dc.identifier.urihttps://hdl.handle.net/20.500.12483/2886
dc.identifier.volume25en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofİnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBiyokimya ve Moleküler Biyolojien_US
dc.subjectAnatomi ve Morfolojien_US
dc.subjectPeriferal Damar Hastalıklarıen_US
dc.subjectKalp ve Kalp Damar Sistemien_US
dc.subjectSolunum Sistemien_US
dc.subjectİmmünolojien_US
dc.subjectDermatolojien_US
dc.subjectGöz Hastalıklarıen_US
dc.subjectPatolojien_US
dc.subjectKlinik Nörolojien_US
dc.subjectOdyoloji ve Konuşma-Dil Patolojisien_US
dc.subjectNörolojik Görüntülemeen_US
dc.subjectRadyolojien_US
dc.subjectNükleer Tıpen_US
dc.subjectTıbbi Görüntülemeen_US
dc.subjectAcil Tıpen_US
dc.subjectTransplantasyonen_US
dc.subjectEnfeksiyon Hastalıklarıen_US
dc.subjectHalk ve Çevre Sağlığıen_US
dc.subjectTıbbi İnformatiken_US
dc.subjectGeriatri ve Gerontolojien_US
dc.subjectNörolojik Bilimleren_US
dc.subjectHematolojien_US
dc.subjectTıbbi Laboratuar Teknolojisien_US
dc.subjectAdli Tıpen_US
dc.subjectTıbbi Etiken_US
dc.subjectKadın Hastalıkları ve Doğumen_US
dc.subjectGastroenteroloji ve Hepatolojien_US
dc.subjectTemel Sağlık Hizmetlerien_US
dc.subjectCerrahien_US
dc.subjectHücre Biyolojisien_US
dc.subjectOrtopedien_US
dc.subjectGenel ve Dahili Tıpen_US
dc.subjectPediatrien_US
dc.subjectTamamlayıcı ve Entegre Tıpen_US
dc.subjectSağlık Bilimleri ve Hizmetlerien_US
dc.subjectBiyokimyasal Araştırma Metotlarıen_US
dc.subjectKulaken_US
dc.subjectBurunen_US
dc.subjectBoğazen_US
dc.subjectTıbbi Araştırmalar Deneyselen_US
dc.subjectPsikiyatrien_US
dc.subjectBiyofiziken_US
dc.subjectYoğun Bakımen_US
dc.subjectTıpen_US
dc.subjectFizyolojien_US
dc.subjectEndokrinoloji ve Metabolizmaen_US
dc.subjectAndrolojien_US
dc.subjectBiyoteknoloji ve Uygulamalı Mikrobiyolojien_US
dc.subjectGelişim Biyolojisien_US
dc.subjectGerontolojien_US
dc.subjectAnestezien_US
dc.subjectRehabilitasyonen_US
dc.subjectOnkolojien_US
dc.subjectMikrobiyolojien_US
dc.subjectSpor Bilimlerien_US
dc.subjectAlerjien_US
dc.subjectTropik Tıpen_US
dc.subjectÜroloji ve Nefrolojien_US
dc.subjectRomatolojien_US
dc.titleThe comparison of the mrna expressions of tgf?1, bfgf, ıgf-1, ngf and matrix metalloprotease iii genes in cervical and lumbar disc tissuesen_US
dc.typeArticleen_US

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