Synthesis and anti-proliferative activity of fluoro-substituted chalcones
Yükleniyor...
Dosyalar
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Pergamon-Elsevier Science Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
A series of novel fluoro-substituted chalcone derivatives have been synthesized. All synthesized compounds were characterized by H-1 nuclear magnetic resonance (NMR), C-13 NMR, and elemental analysis. Their anti-proliferative activities were evaluated against five cancer cells lines, namely, A549, A498, HeLa, A375, and HepG2 using the MTT method. Most of the compounds showed moderate to high activity with IC50 values in the range of 0.029-0.729 mu M. Of all the synthesized compounds, 10 and 19 exhibited the most potent anti-proliferative activities against cancer cells, and 10 was identified as the most promising compound. (C) 2016 Elsevier Ltd. All rights reserved.
Açıklama
Anahtar Kelimeler
Chalcone, Synthesis, Anti-proliferative activity, Organofluorine, Claisen-Schmidt condensation
Kaynak
Bioorganic & Medicinal Chemistry Letters
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
26
Sayı
13
