Synthesis and anti-proliferative activity of fluoro-substituted chalcones

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dc.authoridHAJ ERSAN, RONAK/0000-0001-6651-5910
dc.contributor.authorBurmaoglu, Serdar
dc.contributor.authorAlgul, Oztekin
dc.contributor.authorAnil, Derya Aktas
dc.contributor.authorGobek, Arzu
dc.contributor.authorDuran, Gulay Gulbol
dc.contributor.authorErsan, Ronak Haj
dc.contributor.authorDuran, Nizami
dc.date.accessioned2024-09-18T20:08:12Z
dc.date.available2024-09-18T20:08:12Z
dc.date.issued2016
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractA series of novel fluoro-substituted chalcone derivatives have been synthesized. All synthesized compounds were characterized by H-1 nuclear magnetic resonance (NMR), C-13 NMR, and elemental analysis. Their anti-proliferative activities were evaluated against five cancer cells lines, namely, A549, A498, HeLa, A375, and HepG2 using the MTT method. Most of the compounds showed moderate to high activity with IC50 values in the range of 0.029-0.729 mu M. Of all the synthesized compounds, 10 and 19 exhibited the most potent anti-proliferative activities against cancer cells, and 10 was identified as the most promising compound. (C) 2016 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [114Z554]; Erzincan Universityen_US
dc.description.sponsorshipWe thank the Scientific and Technological Research Council of Turkey (TUBITAK, Grant Number: 114Z554) and Erzincan University for their financial support. Serdar Burmaoglu especially thanks Bilal Altundas for his critical reading of this article.en_US
dc.identifier.doi10.1016/j.bmcl.2016.04.096
dc.identifier.endpage3176en_US
dc.identifier.issn0960-894X
dc.identifier.issn1464-3405
dc.identifier.issue13en_US
dc.identifier.pmid27217001en_US
dc.identifier.scopus2-s2.0-84969584463en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage3172en_US
dc.identifier.urihttps://doi.org/10.1016/j.bmcl.2016.04.096
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8704
dc.identifier.volume26en_US
dc.identifier.wosWOS:000377470600041en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofBioorganic & Medicinal Chemistry Lettersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChalconeen_US
dc.subjectSynthesisen_US
dc.subjectAnti-proliferative activityen_US
dc.subjectOrganofluorineen_US
dc.subjectClaisen-Schmidt condensationen_US
dc.titleSynthesis and anti-proliferative activity of fluoro-substituted chalconesen_US
dc.typeArticleen_US

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