Günübirlik lomber mikrodiskektomi operasyonlarını izleyen postoperatif bulantı kusmanın tedavisinde ondansetrona deksametazon ilavesi
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Tarih
2015
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info:eu-repo/semantics/openAccess
Özet
Amaç: Çalış mam ızda, deksametazonun ondansetronla kombinasyonunun lomber mikrodiskektomilerde postoperatif bulant ı kusmay ı (POBK) önlemedeki etkinliklerini karş ıla ş t ırmay ı amaçladık. Gereç ve Yöntem: Günübirlik mikrodiskektomi operasyonu uygulanacak American Society of Anesthesiologists (ASA) I-II, 60 hasta rastgele 3 gruba ayr ıldı: grup D; 8mg deksametazon, grup O; 4mg ondansetron, grup P; 8mg deksametazon ve 4mg ondansetron. Postoperatif bulantı ve kusma ve a ğ r ı s ıklığ ı ile antiemetik ve analjezik ihtiyaçlar ı cerrahi sonras ında 3-12 ve 24. saatlerde de ğ erlendirildi. Bulgular: Postoperatif ilk 3 saatte bulantı insidans ı grup D ve grup O’ya kıyasla grup P’de anlamlı olarak azalm ış t ı (p<0.046 ve p<0.021, s ıras ıyla). Bu dönemde ilave antiemetik kullanım ı, grup P’de grup D ve grup O’ya kıyasla anlamlı olarak azalm ış tı (p<0.030 ve p<0.023, s ıras ıyla). Çalış mam ızda; kadın cinsiyet, sigara içmeme, POBK veya ta ş ıt tutma hikâyesi POBK’nın tahmininde anlamlı risk faktörleriydi. Oral su/g ıda alma zamanı ve taburcu olma süreleri diğ er gruplara kıyasla grup P’de anlamlı olarak azalm ış ken (p<0.012, p<0.003 ve p<0.005, p<0.007, s ıras ıyla), POBK görülen hastalarda ise anlamlı olarak artm ış tı (p<0.007 ve p<0.029, s ıras ıyla). Sonuç: Günübirlik lomber mikrodiskektomilerde deksametazonun ondansetronla kombinasyonu antiemetik etkinliğ i arttırarak hastaların daha erken oral su/g ıda almalar ını ve daha erken taburcu olmalarını sa ğ lam ış tır.
Objevtive: The aim of this study was to determine the effect of the combination of dexamethasone with ondansetron on postoperative nausea and vomiting (PONV) in patients undergoing lumbar microdiscectomy. Methods: ASA I–II, sixty patients undergoing day- case lumbar microdiscectomy were randomized into three groups: group D; (n=20) 8 mg dexamethasone, group O; (n=20) 4 mg ondansetron and group P; (n=20) 8 mg dexamethasone-4 mg ondansetron. The incidence of PONV and pain, the needs of antiemetics and analgesic were recorded 3-12 and 24th hours postoperatively. Results: The incidence of postoperative nausea in the first 3 hours was shorter in group P compared with group D and group O (p<0.046 and p<0.021, respectively). During this period, rescue antiemetic use was significantly decreased in group P compared with group D and group O (p<0.030 and p<0.023, respectively). Female gender, nonsmoking, history of motion sickness or PONV were risk factors for PONV. The oral water/nutrition intake and discharge time in group P was significantly decreased compared with the other groups (p<0.012, p<0.003 and p<0.005, p<0.007, respectively). It was significantly increased in patients who experienced PONV (p<0.007 and p<0.029, respectively). Conclusion: The combination of dexamethasone with ondasetron provided earlier oral water/nutrition intake and earlier discharge time by significantly increasing the antiemetic effectiveness.
Objevtive: The aim of this study was to determine the effect of the combination of dexamethasone with ondansetron on postoperative nausea and vomiting (PONV) in patients undergoing lumbar microdiscectomy. Methods: ASA I–II, sixty patients undergoing day- case lumbar microdiscectomy were randomized into three groups: group D; (n=20) 8 mg dexamethasone, group O; (n=20) 4 mg ondansetron and group P; (n=20) 8 mg dexamethasone-4 mg ondansetron. The incidence of PONV and pain, the needs of antiemetics and analgesic were recorded 3-12 and 24th hours postoperatively. Results: The incidence of postoperative nausea in the first 3 hours was shorter in group P compared with group D and group O (p<0.046 and p<0.021, respectively). During this period, rescue antiemetic use was significantly decreased in group P compared with group D and group O (p<0.030 and p<0.023, respectively). Female gender, nonsmoking, history of motion sickness or PONV were risk factors for PONV. The oral water/nutrition intake and discharge time in group P was significantly decreased compared with the other groups (p<0.012, p<0.003 and p<0.005, p<0.007, respectively). It was significantly increased in patients who experienced PONV (p<0.007 and p<0.029, respectively). Conclusion: The combination of dexamethasone with ondasetron provided earlier oral water/nutrition intake and earlier discharge time by significantly increasing the antiemetic effectiveness.
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Cerrahi
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Van Tıp Dergisi
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Scopus Q Değeri
Cilt
22
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1
