The androgenic profile of women with type I and type II diabetes mellitus

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dc.contributor.authorErtunç, Devrim
dc.contributor.authorTok, Celalettin Ekrem
dc.contributor.authorPatai Özlem
dc.contributor.authorDilek, Umut
dc.contributor.authorKaplanoğlu, Mustafa
dc.contributor.authorDilek, Saffet
dc.date.accessioned2019-07-16T15:47:50Z
dc.date.available2019-07-16T15:47:50Z
dc.date.issued2004
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractOBJECTIVE: Some evidence suggests that the diabetic patients share some of the features of women with polycystic ovary syndrome. To address this issue, we attempted to evaluate the androgenic profile of women with type I and type II diabetes mellitus. STUDY DESIGN: We evaluated the clinical, hormonal and ultrasonographic variables in women with type I and type II diabetes mellitus at reproductive age, and compared with age- and weight matched controls. The prevalence of polycystic ovary syndrome, hirsutismus, acne and temporal balding were investigated. Serum levels of total testosterone, estradiol, DHEAS, androstenedione, SHBG, LH and FSH were evaluated. Ovarian appearance and volume were assessed by transvaginal or transabdominal ultrasonography. RESULTS: The prevalence of polycystic ovary syndrome was found higher in diabetic patients than the prevalence in general population that reported earlier. Hirsutismus was also more prevalent in diabetic patients (p<0,05). The levels of FSH, LH, estradiol, total testosterone and androstenedione were significantly higher in diabetic patients than in control group (p<0,05), but, they did not differ among diabetes mellitus subtype. The levels of DHEAS and SHBG were comparable among the study groups. Although the rates of ultrasonographically polycystic ovary appearance and ovarian volumes were higher than in control group, the difference did not reach statistical significance (p>0,05). CONCLUSION: The results of this study suggest that women with diabetes mellitus have biochemical and clinical hyperandrogenism when compared with non-diabetic controls. To confirm this issue, large population-based studies with both types of diabetes mellitus should be performed.en_US
dc.description.abstractOBJECTIVE: Some evidence suggests that the diabetic patients share some of the features of women with polycystic ovary syndrome. To address this issue, we attempted to evaluate the androgenic profile of women with type I and type II diabetes mellitus. STUDY DESIGN: We evaluated the clinical, hormonal and ultrasonographic variables in women with type I and type II diabetes mellitus at reproductive age, and compared with age- and weight matched controls. The prevalence of polycystic ovary syndrome, hirsutismus, acne and temporal balding were investigated. Serum levels of total testosterone, estradiol, DHEAS, androstenedione, SHBG, LH and FSH were evaluated. Ovarian appearance and volume were assessed by transvaginal or transabdominal ultrasonography. RESULTS: The prevalence of polycystic ovary syndrome was found higher in diabetic patients than the prevalence in general population that reported earlier. Hirsutismus was also more prevalent in diabetic patients (p<0,05). The levels of FSH, LH, estradiol, total testosterone and androstenedione were significantly higher in diabetic patients than in control group (p<0,05), but, they did not differ among diabetes mellitus subtype. The levels of DHEAS and SHBG were comparable among the study groups. Although the rates of ultrasonographically polycystic ovary appearance and ovarian volumes were higher than in control group, the difference did not reach statistical significance (p>0,05). CONCLUSION: The results of this study suggest that women with diabetes mellitus have biochemical and clinical hyperandrogenism when compared with non-diabetic controls. To confirm this issue, large population-based studies with both types of diabetes mellitus should be performed.en_US
dc.identifier.endpage113en_US
dc.identifier.issn1300-4751
dc.identifier.issue2en_US
dc.identifier.startpage109en_US
dc.identifier.urihttps://trdizin.gov.tr/publication/paper/detail/TXpnME16VTE=
dc.identifier.urihttps://hdl.handle.net/20.500.12483/806
dc.identifier.volume10en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofGORM:Gynecology Obstetrics & Reproductive Medicineen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectKadın Hastalıkları ve Doğumen_US
dc.titleThe androgenic profile of women with type I and type II diabetes mellitusen_US
dc.typeArticleen_US

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