Vitiligolu hastalarda retina pigment epitel kalınlığının optik koherans tomografi ile analizi
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Tarih
2015
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Vitiligolu erişkin bireylerde eşlik eden göz bulgularının araştırılması ve optik koherans tomografi (OKT) ile retina pigment epitel (RPE) kalınlığı analizi. Gereç ve Yöntem: Vitiligolu 30 hasta ve sağlıklı 39 bireyin dahil edildiği çalışma prospektif olarak yürütüldü. Katılımcılar detaylı bir göz muayenesine tabi tutuldu, ayrıca OKT ile RPE kalınlık ölçümleri yapıldı.Bulgular: Vitiligolu hastaların yaş ortalaması 37,5±15,5 (18-62 yıl), kontrol grubunun yaş ortalaması ise 38,6±11,0 (21-61 yıl) idi. Vitiligo grubunun %40'ında perioküler vitiligo lezyonları, %20'sinde poliozis, %16,7'sinde iris atrofisi, %3,3'ünde makülada hipopigmente lezyon saptandı.Vitiligolu hastaların ve kontrol grubunun RPE kalınlık ortalamaları sırasıyla 63,3±3,0 µm ve 64,3±1,7 µm idi. Gruplar arasında RPE kalınlık ortalamaları açısından istatistiksel olarak fark saptanmadı (p=0,07). Perioküler vitiligo lezyonları olan ve olmayan hastaların RPE kalınlık ortalamaları sırasıyla 63,0±3,1 µm ve 65,0±2,4 µm idi. Perioküler tutulumu olanlar ve olmayanlar arasında RPE kalınlık ortalamaları açısından istatistiksel olarakfark saptanmadı (p=0,06).Sonuç: Vitiligoda perioküler cilt lezyonları ve poliozis sık görülmekle birlikte iris ve retinada hipopigmente lezyonlar da görülebilmektedir. Vitiligoher ne kadar pigment miktarını etkilese de, RPE hücrelerinin kalınlığını etkilememektedir.
Objective: To investigate the ocular findings of adult individuals with vitiligo and analysis of retinal pigment epithelium (RPE) thickness using optical coherence tomography (OCT). Material and Method: The study was conducted prospectively and comprised 30 patients with vitiligo and 39 healthy individuals. A detailed ophthalmological examination was performed and also, thickness of RPE measurements was obtained using OCT. Results: The mean age of the patients with vitiligo was 37.5±15.5 (18-62 years), while the mean age of the control group was 38.6±11.0 (21-61 years). There were 40% periocular vitiligo lesions, 20% poliosis, 16.7% iris atrophy, 3.3% macular hypopigmented lesion in the vitiligo group. The mean thickness of RPE in patients with vitiligo and control group was 63.3±3.0 ?m and 64.3±1.7 ?m, respectively. There was no statistically significant difference between groups in terms of the mean thickness of the RPE (p=0.07). The mean thickness of RPE in patients with and without periocular vitiligo lesions was 63.0±3.1 ?m and 65.0±2.4 ?m, respectively. No statistically significant difference was detected between periocular involvement and the mean thickness of the RPE (p=0.06). Conclusion: Periocular skin lesions and poliosis are common in vitiligo, although hypopigmented lesions can be seen in the iris and retina. Although vitiligo affects the amount of pigment, it does not affect the thickness of RPE cells.
Objective: To investigate the ocular findings of adult individuals with vitiligo and analysis of retinal pigment epithelium (RPE) thickness using optical coherence tomography (OCT). Material and Method: The study was conducted prospectively and comprised 30 patients with vitiligo and 39 healthy individuals. A detailed ophthalmological examination was performed and also, thickness of RPE measurements was obtained using OCT. Results: The mean age of the patients with vitiligo was 37.5±15.5 (18-62 years), while the mean age of the control group was 38.6±11.0 (21-61 years). There were 40% periocular vitiligo lesions, 20% poliosis, 16.7% iris atrophy, 3.3% macular hypopigmented lesion in the vitiligo group. The mean thickness of RPE in patients with vitiligo and control group was 63.3±3.0 ?m and 64.3±1.7 ?m, respectively. There was no statistically significant difference between groups in terms of the mean thickness of the RPE (p=0.07). The mean thickness of RPE in patients with and without periocular vitiligo lesions was 63.0±3.1 ?m and 65.0±2.4 ?m, respectively. No statistically significant difference was detected between periocular involvement and the mean thickness of the RPE (p=0.06). Conclusion: Periocular skin lesions and poliosis are common in vitiligo, although hypopigmented lesions can be seen in the iris and retina. Although vitiligo affects the amount of pigment, it does not affect the thickness of RPE cells.
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MN Oftalmoloji
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22
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1
