Evaluation of dynamic thiol-disulfide balance and ischemia modified albumin levels in patients with chronic kidney disease

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dc.contributor.authorErdal, Hüseyin
dc.contributor.authorÖzcan, Oğuzhan
dc.contributor.authorTurgut, Faruk Hilmi
dc.contributor.authorNeselioglu, Salim
dc.contributor.authorErel, Özcan
dc.date.accessioned2024-09-19T16:22:10Z
dc.date.available2024-09-19T16:22:10Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: In this study, it was aimed to determine the dynamic thiol-disulfide balance and ischemia modified albumin (IMA) levels in patients with chronic kidney disease (CKD). Method: Thirty hemodialysis (HD), 30 CKD patients (stage 3-5) and 30 controls were included in the study. The dynamic thiol-disulfide balance was determined by the colorimetric method developed by Erel et al. IMA levels were determined by using cobalt binding test developed by Bar- Or et al. Results: Native and total thiol levels of CKD and HD patients were significantly lower than that of the control group (p=0.001 for both). However, disulfide levels were significantly higher in the HD group (p=0.001), but there was no significant difference between control and CKD groups(p=0.547). A statistically significant negative correlation was found between the native and total thiol levels and IMA (r=-0.628; -0.631), BUN (r=-0.747; -0.747), and creatinine (r=-0.732; -0.721). There was a significant positive correlation between GFR and the thiol levels (r=0.835;0.824). TrxR levels were significantly higher in the patient groups compared to the controls (p=0.001). CRP levels of the patient groups were significantly higher compared to the controls (p=0.001). Conclusion: We have demonstrated that measurement of dynamic thiol-disulfide levels by using colorimetric method can contribute to the diagnosis and follow-up of the disease as a marker, because it is easily applicable in routine clinical biochemistry laboratories and related with disease severity in CKD patients. Also, we showed that albumin correction due to dialysis process should be consider in studies dealing with plasma thiol values and the final results should be given after the correction process.en_US
dc.identifier.doi10.17944/mkutfd.947113
dc.identifier.endpage242en_US
dc.identifier.issn2149-3103
dc.identifier.issue47en_US
dc.identifier.startpage237en_US
dc.identifier.trdizinid1144325en_US
dc.identifier.urihttps://doi.org/10.17944/mkutfd.947113
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1144325
dc.identifier.urihttps://hdl.handle.net/20.500.12483/15665
dc.identifier.volume13en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofMustafa Kemal Üniversitesi Tıp Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChronic kidney diseaseen_US
dc.subjecthemodialysisen_US
dc.subjectoxidative stressen_US
dc.subjectthiol- disulphide homeostasisen_US
dc.subjectischemia modified albuminen_US
dc.titleEvaluation of dynamic thiol-disulfide balance and ischemia modified albumin levels in patients with chronic kidney diseaseen_US
dc.typeArticleen_US

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