Incidence and predictors of direct-acting antiviral treatment failure in Turkish patients with chronic hepatitis C genotype 1b infection
Loading...
Date
2020
Journal Title
Journal ISSN
Volume Title
Publisher
Sage Publications Inc
Access Rights
info:eu-repo/semantics/closedAccess
Abstract
Evaluation of the incidence and predictors of failure of direct-acting antiviral treatment for hepatitis C virus genotype 1b patients is important. Our retrospective cohort study assessed 172 Turkish patients who had received a full course of such treatment and could be checked for sustained virologic response. The overall treatment failure rate was 2.9% (5/172), all of whom relapsed. In three of these cases with sequencing data available, all had NS5A resistance-associated substitution. Multivariate analysis revealed that a 1 mg/dL increase in pre-treatment total bilirubin level was associated with a sevenfold increased likelihood of treatment failure. The baseline level of total bilirubin was the only significant independent predictor of direct-acting antiviral treatment failure.
Description
Keywords
Chronic hepatitis C virus infection, direct-acting antivirals, genotype 1b, interferon-free, sustained virologic response
Journal or Series
Tropical Doctor
WoS Q Value
Q4
Scopus Q Value
Q3
Volume
50
Issue
2
