Incidence and predictors of direct-acting antiviral treatment failure in Turkish patients with chronic hepatitis C genotype 1b infection

Basit Öğe Kaydı
dc.contributor.authorCabalak, Mehmet
dc.contributor.authorBal, Tayibe
dc.contributor.authorOnlen, Yusuf
dc.contributor.authorDemir, Mehmet
dc.date.accessioned2024-09-18T20:08:25Z
dc.date.available2024-09-18T20:08:25Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractEvaluation of the incidence and predictors of failure of direct-acting antiviral treatment for hepatitis C virus genotype 1b patients is important. Our retrospective cohort study assessed 172 Turkish patients who had received a full course of such treatment and could be checked for sustained virologic response. The overall treatment failure rate was 2.9% (5/172), all of whom relapsed. In three of these cases with sequencing data available, all had NS5A resistance-associated substitution. Multivariate analysis revealed that a 1 mg/dL increase in pre-treatment total bilirubin level was associated with a sevenfold increased likelihood of treatment failure. The baseline level of total bilirubin was the only significant independent predictor of direct-acting antiviral treatment failure.en_US
dc.identifier.doi10.1177/0049475519892082
dc.identifier.endpage146en_US
dc.identifier.issn0049-4755
dc.identifier.issn1758-1133
dc.identifier.issue2en_US
dc.identifier.pmid31810415en_US
dc.identifier.scopus2-s2.0-85077379257en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage141en_US
dc.identifier.urihttps://doi.org/10.1177/0049475519892082
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8821
dc.identifier.volume50en_US
dc.identifier.wosWOS:000501134200001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofTropical Doctoren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChronic hepatitis C virus infectionen_US
dc.subjectdirect-acting antiviralsen_US
dc.subjectgenotype 1ben_US
dc.subjectinterferon-freeen_US
dc.subjectsustained virologic responseen_US
dc.titleIncidence and predictors of direct-acting antiviral treatment failure in Turkish patients with chronic hepatitis C genotype 1b infectionen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ N/A ]
İsim:
Tam Metin / Full Text
Boyut:
268.07 KB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu