Hatay yöresindeki gebelerde toksoplazma lgG seroprevalansı ve avidite testinin tanıya katkısı
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Tarih
2013
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Zorunlu hücre içi paraziti olan Toxoplazma gondii, dünyada sık görülen bir zoonoz olup, toksoplazmozis enfeksiyonuna neden olur. Enfeksiyon genellikle asemptomatik seyretmekle birlikte gebelik döneminde geçirildiğinde konjenital anomalili doğumlara, düşüklere, ölü doğum ve prematür doğuma neden olabilmektedir. Bu çalışmada, Hatay yöresindeki gebelerde Toxoplasma IgG ve IgM seroprevalansının saptanması amaçlanmıştır. Planlama: Çalışmaya 2007-2012 yılları arasında Hatay Mustafa Kemal Üniversitesi Kadın Hastalıkları ve Doğum polikliniğine başvuran 3340 gebe dahil edildi. Hastanemiz mikrobiyoloji laboratuvar kayıtları taranarak olguların Toxoplasma IgM ve IgG antikor test sonuçları retrospektif olarak incelendi. Toxoplazma IgM ve IgG testlerinin her ikisi birden pozitif olan 114 olguda ise IgG avidite testi yapıldı. Olgulara avidite testine göre tedavi, takip veya gebeliğin sonlandırılması önerildi. Değerlendirme parametreleri: Araştırmada % 3,6 (n:120 ) oranında IgM pozitişiği ve % 57 (n:1910 ) oranında ise IgG seropozitişiği saptandı. Avidite testi ile % 31 olguda yeni enfeksiyon tespit edildi. Yorum: Çalışmada Akdeniz bölgesinde özellikle Hatay ve yöresinde parazitin seropozitişiğinin dikkate değer düzeyde yüksek olduğu gözlenmiş olduğundan özellikle birinci trimesterdeki gebelerin ve gebelik planlayan kadınların rutin muayenelerinde Toxoplasma gondii antikor testi yapılması faydalı olabilir. Ayrıca, bölgemizde su ve hijyen açısından bilincin arttırılması için tedbirler alınmalıdır.
Objective: Toxoplasma gondii, an obligate intracellular parasite, is a common zoonosis in the world and causes toxoplasmosis. The infection is usually asymptomatic and if it occurs during pregnancy it may cause congenital anomalies, miscarriage, stillbirth and premature delivery. In this study, determination of seroprevalance of Toxoplasma IgG and IgM among pregnant women in the province of Hatay was aimed. In addition, IgG avidity test was performed in subjects who had positive test results for both of the two antibodies. Design: In this study, 3340 pregnant women who admitted to the outpatient clinic of Gynecology and Obstetrics Department of Mustafa Kemal University between the years of 2007 and 2012 were included. Toxoplasma IgM and IgG antibody test results of the subjects were examined retrospectively by screening the records of microbiology laboratory of the hospital. Additionally, IgG avidity test was performed in 114 cases whose test results for both Toxoplasma IgM and IgG were positive. Main outcome measures: IgM and IgG seropositivity rates were found as 3.6% (n :120) and 57% (n:1910), respectively. The rate of new infection was detected with avidity test as 31%. Conclusions: Since remarkably high seropositivity rate was observed in the Mediterranean region especially in the province of Hatay, antibody testing for Toxoplasma gondii may be useful during routine examinations of women who are in this region. In addition, measures should be taken to raise awareness of hygiene in our region in terms of water and sanitation.
Objective: Toxoplasma gondii, an obligate intracellular parasite, is a common zoonosis in the world and causes toxoplasmosis. The infection is usually asymptomatic and if it occurs during pregnancy it may cause congenital anomalies, miscarriage, stillbirth and premature delivery. In this study, determination of seroprevalance of Toxoplasma IgG and IgM among pregnant women in the province of Hatay was aimed. In addition, IgG avidity test was performed in subjects who had positive test results for both of the two antibodies. Design: In this study, 3340 pregnant women who admitted to the outpatient clinic of Gynecology and Obstetrics Department of Mustafa Kemal University between the years of 2007 and 2012 were included. Toxoplasma IgM and IgG antibody test results of the subjects were examined retrospectively by screening the records of microbiology laboratory of the hospital. Additionally, IgG avidity test was performed in 114 cases whose test results for both Toxoplasma IgM and IgG were positive. Main outcome measures: IgM and IgG seropositivity rates were found as 3.6% (n :120) and 57% (n:1910), respectively. The rate of new infection was detected with avidity test as 31%. Conclusions: Since remarkably high seropositivity rate was observed in the Mediterranean region especially in the province of Hatay, antibody testing for Toxoplasma gondii may be useful during routine examinations of women who are in this region. In addition, measures should be taken to raise awareness of hygiene in our region in terms of water and sanitation.
Açıklama
Anahtar Kelimeler
Cerrahi
Kaynak
Türk Jinekoloji ve Obstetrik Derneği Dergisi
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Scopus Q Değeri
Cilt
10
Sayı
3
