Effect of vitamin D in experimental varicocele model in rats

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dc.authoridAGTURK, GOKHAN/0000-0002-5573-6715
dc.authoridOzgur, Tumay/0000-0002-5291-4483
dc.authoridozcan, oguzhan/0000-0001-7486-503X
dc.contributor.authorAgturk, Gokhan
dc.contributor.authorTumer, Cemil
dc.contributor.authorTutuk, Okan
dc.contributor.authorGocmen, Hatice Dogan
dc.contributor.authorOzgur, Tumay
dc.contributor.authorOzcan, Oguzhan
dc.contributor.authorDuran, Gulay Gulbol
dc.date.accessioned2024-09-18T21:00:32Z
dc.date.available2024-09-18T21:00:32Z
dc.date.issued2024
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPurpose: Varicocele is a pathological condition that affects approximately 20% of adult men, causing infertility and sperm deterioration. The aim of our study was to investigate the efficacy of vitamin D (Vit. D) in the pathophysiology of varicocele. We performed biochemical, gene expression analyses and histopathological to evaluate the efficacy of vitamin D in the experimental varicocele model. Materials and Methods: In the study, 30 adult male Wistar Albino rats were used. The rats were divided into 3 groups equally as control group, experimental group (varicocele), treatment group (varicocele + D vit.). The treatment group received 500 IU/kg D vit. intramuscularly. Results: Histopathological, TRPM2-8 gene expression and biochemical analyses were performed on testicular and blood samples collected at the end of the experiment. The experimental group showed a deterioration in tubular structure, a decrease in total antioxidant levels and an increase in total oxidant levels. The treatment group, on the other hand, showed an increase in TAS, a decrease in TOS and a beneficial improvement in tubular structure disorders. Analysis of gene expression levels showed that TRPM2-8 expression levels were significantly increased in the varicocele group and decreased in the treatment group. Conclusion: In the varicocele model, the use of vitamin D had a significant effect on TRPM2-8 gene level, pathological seminiferous tubules and biochemical values. Further studies are needed to determine the clinical application of vitamin D in varicocele disease.en_US
dc.description.sponsorshipHatay Mustafa Kemal University Scientific Research Projects Unit [16562]en_US
dc.description.sponsorshipThis study received a special grant from Hatay Mustafa Kemal University Scientific Research Projects Unit with project number 16562.en_US
dc.identifier.doi10.17826/cumj.1395542
dc.identifier.endpage103en_US
dc.identifier.issn2602-3032
dc.identifier.issn2602-3040
dc.identifier.issue1en_US
dc.identifier.startpage97en_US
dc.identifier.trdizinid1230884en_US
dc.identifier.urihttps://doi.org/10.17826/cumj.1395542
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1230884
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12750
dc.identifier.volume49en_US
dc.identifier.wosWOS:001202449400001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherCukurova Univ, Fac Medicineen_US
dc.relation.ispartofCukurova Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectVaricoceleen_US
dc.subjectTRPMen_US
dc.subjectVitamin Den_US
dc.subjectTASen_US
dc.subjectTOSen_US
dc.titleEffect of vitamin D in experimental varicocele model in ratsen_US
dc.typeArticleen_US

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