Plasenta yerleşim ve adezyon anomalilerinde hücre adezyon moleküllerinin (E-selektin, P-selektin, ICAM-1, VCAM-1, LRG-1 ) serum düzeylerinin vajinal doğumlu ve eski sezaryenli hastalarla karşılaştırılması
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Tarih
2022
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Hatay Mustafa Kemal Üniversitesi
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info:eu-repo/semantics/openAccess
Özet
Amaç: Plasenta yerleşim ve adezyon anomalilerinde hücre adezyon moleküllerinin yeri araştırılmıştır. Gereç ve Yöntem: Çalışmaya, Mart 2020 ile Eylül 2021 tarihleri arasındaki hastalar alınmıştır. 18-50 yaş, 153 olgudan 56 hasta plasenta yapışma ve/veya yerleşim anomalisi grubunu oluştururken, plasenta yapışma anomalisi (plasenta invazyon anomalisi ve/veya previa patolojisi) bulunmayan 55 olgu sezaryen grubunu ve 42 olgu vajinal doğum kontrol grubunu oluşturdu. 153 hastanın demografik özellikleri, özgeçmişleri sorgulandı. I-CAM-1, V-CAM-1, E-Selektin, P-Selektin, LRG-1 düzeyleri çalışıldı. Bulgular: Gruplar arasında E-Selectin, P-Selectin, ICAM-1 ve LRG-1 değerlerinde anlamlı farklılıklar olduğu tespit edildi (p<0,05). NVD ve PP grupları arasında E-Selectin açısından anlamlı fark olduğu görüldü (p=0,038). P-Selectin açısından ise C/S ve PP grupları arasında anlamlı bir fark olduğu belirlendi (p=001). P-Selectin PP grubunda daha yüksek izlendi. ICAM-1 açısından NVD, C/S grubu (p=0,041) ve NVD, PP grubu (p=0,013) arasında anlamlı fark izlendi, C/S ve PP grubu arasında anlamlı fark görülmedi. LRG-1 açısından ise her 3 grup arasında anlamlı bir fark olduğu tespit edildi (p<0,05). Sonuç: Plasenta invazyon anomalilerinin altta yatan mekanizması halen belirsiz olmasına rağmen kronik inflamasyon, düşük maternal vasküler kan akımı ve hemoraji ile bağlantılı histopatolojik bir mekanizma ile ilgili olabileceği gösterilmiştir. Bu nedenle bazı inflamasyon, invazyon ve adezyon moleküllerinin bu süreçte rol oynayabileceği düşünülmüştür. Çalışmamızda V-CAM-1 hariç tüm adezyon molekülleri PP grubunda anlamlı yüksek saptandı. E-Selektin ve LRG-1 adezyon moleküllerinde ise normal doğuma göre C/S hastalarında dahi anlamlı yüksek saptandı. Sonuç olarak; bu adezyon molekülleri PP hastalarında bir marker olarak çalışılabilir. Anahtar Sözcükler: Plasenta previa, Plasenta akreata, E-Selectin, P-Selectin, ICAM-1, VCAM-1, LRG-1
Objective: The effect of cell adhesion molecules on placental location and adhesion anomalies was investigated. Materials and Methods: Patients between March 2020 and September 2021 were included in the study. While 56 patients aged 18-50 years, out of 153 cases formed the placental adhesion and/or localization anomaly group, 55 cases without placental adhesion anomaly (placental invasion anomaly and/or previa pathology) constituted the cesarean section group and 42 cases constituted the vaginal birth control group. Demographic characteristics and histories of 153 patients were questioned. I-CAM-1, V-CAM-1, E-Selectin, P-Selectin, LRG-1 levels were studied. Results: There were significant differences in E-Selectin, P-Selectin, ICAM-1 and LRG-1 values between the groups (p<0.05). There was a significant difference between the NVD and PP groups in terms of E-Selectin (p=0.038). In terms of P-Selectin, there was a significant difference between the C/S and PP groups (p=001). P-Selectin was higher in the PP group. There was a significant difference between the NVD, C/S group (p=0.041) and the NVD, PP group (p=0.013) in terms of ICAM-1, but there was no significant difference between the C/S and PP groups. In terms of LRG-1, there was a significant difference between all 3 groups (p<0.05). Conclusions: Although the underlying mechanism of placental invasion anomalies is still unclear, it has been shown that it may be related to a histopathological mechanism associated with chronic inflammation, low maternal vascular blood flow and hemorrhage. Therefore, it is thought that some inflammation, invasion and adhesion molecules may play a role in this process. In our study, all adhesion molecules except V-CAM-1 were found to be significantly higher in the PP group. E-Selectin and LRG-1 adhesion molecules were found to be significantly higher even in C/S patients compared to normal delivery. As a result; these adhesion molecules can be studied as a marker in PP patients.
Objective: The effect of cell adhesion molecules on placental location and adhesion anomalies was investigated. Materials and Methods: Patients between March 2020 and September 2021 were included in the study. While 56 patients aged 18-50 years, out of 153 cases formed the placental adhesion and/or localization anomaly group, 55 cases without placental adhesion anomaly (placental invasion anomaly and/or previa pathology) constituted the cesarean section group and 42 cases constituted the vaginal birth control group. Demographic characteristics and histories of 153 patients were questioned. I-CAM-1, V-CAM-1, E-Selectin, P-Selectin, LRG-1 levels were studied. Results: There were significant differences in E-Selectin, P-Selectin, ICAM-1 and LRG-1 values between the groups (p<0.05). There was a significant difference between the NVD and PP groups in terms of E-Selectin (p=0.038). In terms of P-Selectin, there was a significant difference between the C/S and PP groups (p=001). P-Selectin was higher in the PP group. There was a significant difference between the NVD, C/S group (p=0.041) and the NVD, PP group (p=0.013) in terms of ICAM-1, but there was no significant difference between the C/S and PP groups. In terms of LRG-1, there was a significant difference between all 3 groups (p<0.05). Conclusions: Although the underlying mechanism of placental invasion anomalies is still unclear, it has been shown that it may be related to a histopathological mechanism associated with chronic inflammation, low maternal vascular blood flow and hemorrhage. Therefore, it is thought that some inflammation, invasion and adhesion molecules may play a role in this process. In our study, all adhesion molecules except V-CAM-1 were found to be significantly higher in the PP group. E-Selectin and LRG-1 adhesion molecules were found to be significantly higher even in C/S patients compared to normal delivery. As a result; these adhesion molecules can be studied as a marker in PP patients.
Açıklama
Anahtar Kelimeler
Kadın Hastalıkları ve Doğum, Obstetrics and Gynecology, Placenta previa, Placenta accreata, E-Selectin, P-Selectin, ICAM-1, VCAM-1,LRG-1
