In vitro genotoxicity assessment of the synthetic plant growth regulator, 1-naphthaleneacetamide

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dc.contributor.authorKocaman, Ayse Yavuz
dc.contributor.authorGuven, Banu
dc.date.accessioned2024-09-18T19:47:57Z
dc.date.available2024-09-18T19:47:57Z
dc.date.issued2016
dc.departmentHatay Mustafa Kemal Ãœniversitesien_US
dc.description.abstract1-Naphthaleneacetamide (NAAm) is a synthetic plant growth regulator in the auxin family that is widely used in agriculture to promote the growth of numerous fruits, for root cuttings and as a fruit thinning agent. The potential genotoxic effects of NAAm were investigated in vitro by the chromosome aberrations (CAs), and cytokinesis-block micronucleus assays in human peripheral blood lymphocytes (PBLs) for the first time. The human PBLs were treated with 20, 40, 80, and 160 A mu g/mL of NAAm for 24 and 48 h. The results of this study showed that NAAm significantly induced the formation of structural CA and MN for all concentrations (20, 40, 80 and 160 A mu g/mL) and treatment periods (24 and 48 h) when compared with the negative and the solvent control. In addition, the higher concentrations of NAAm (80 and 160 A mu g/mL) caused a statistically significant increase in nuclear bud (NBUD) formation for both 24 and 48 h treatment times. With regard to the cell cycle kinetics, at all the tested concentrations, NAAm caused a statistically significant reduction in the mitotic index (MI) only for 48 h treatment period and also in the nuclear division index (NDI) for both 24 and 48 h treatment periods as compared to the control groups. The reductions in the MI and NDI occured in a concentration-dependent manner for both treatment times. In conclusion, the present results indicate that in the tested experimental conditions, NAAm was genotoxic and cytotoxic on human PBLs in vitro.en_US
dc.description.sponsorshipMustafa Kemal University Research Fund [281]en_US
dc.description.sponsorshipThis study was funded by Mustafa Kemal University Research Fund (project code: 281).en_US
dc.identifier.doi10.1007/s10616-015-9847-z
dc.identifier.endpage956en_US
dc.identifier.issn0920-9069
dc.identifier.issn1573-0778
dc.identifier.issue4en_US
dc.identifier.pmid25690333en_US
dc.identifier.scopus2-s2.0-84923239688en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage947en_US
dc.identifier.urihttps://doi.org/10.1007/s10616-015-9847-z
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7244
dc.identifier.volume68en_US
dc.identifier.wosWOS:000380265300034en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofCytotechnologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject1-Naphthaleneacetamideen_US
dc.subjectSynthetic plant growth regulatoren_US
dc.subjectChromosome aberrationen_US
dc.subjectMicronucleusen_US
dc.subjectHuman peripheral blood lymphocytesen_US
dc.titleIn vitro genotoxicity assessment of the synthetic plant growth regulator, 1-naphthaleneacetamideen_US
dc.typeArticleen_US

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