Polymer – flufenamic acid delivery systems for injured skin

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dc.contributor.authorMarin, Maria Minodora
dc.contributor.authorGhıca, Mihaela Violeta
dc.contributor.authorKaya, Durmuş Alpaslan
dc.contributor.authorUdeanu, Denisa Ioana
dc.contributor.authorKaya, Madalina Albu
dc.contributor.authorDinu-Pirvu, Cristina-Elena
dc.contributor.authorPopa, Lacramıoara
dc.date.accessioned2024-09-19T16:23:38Z
dc.date.available2024-09-19T16:23:38Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractCollagen, the main protein of the body, is extracted in different forms and used as reservoir for drug delivery. The aim of this work was to obtain a drug delivery system based on collagen-dextran matrices cross-linked with glutaraldehyde as support and flufenamic acid and/or microcapsules with flufenamic acid as drug. The flufenamic acid was encapsulated in polymeric microcapsules consisting in gelatin, alginate, and sodium carboxymethyl cellulose. The morphology of matrices was determined by water absorption and contact angle. The biodegradation was performed in collagenase solution. In vitroflufenamic acid release profiles were built and the kinetic mechanism was set according to different mathematical models. The pharmacological studies followed the effect of collagen formulations treatment on the healing process of Wistar rats which were induced experimental wounds. The studied matrices proved that flufenamic acid delivery can be controlled, and the healing can be completed using the designed spongious matrices.en_US
dc.identifier.doi10.32571/ijct.1135548
dc.identifier.endpage121en_US
dc.identifier.issn2602-277X
dc.identifier.issue2en_US
dc.identifier.startpage114en_US
dc.identifier.trdizinid1159205en_US
dc.identifier.urihttps://doi.org/10.32571/ijct.1135548
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1159205
dc.identifier.urihttps://hdl.handle.net/20.500.12483/16022
dc.identifier.volume6en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofInternational Journal of Chemistry and Technology (IJCT)en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCollagen spongesen_US
dc.subjectmicrocapsulesen_US
dc.subjectflufenamic aciden_US
dc.subjectkinetic releaseen_US
dc.subjectwound healingen_US
dc.titlePolymer – flufenamic acid delivery systems for injured skinen_US
dc.typeArticleen_US

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