Effects of Bovine Amniotic Fluid on Acute Corneal Alkali Burns in the Rat
[ N/A ]
Tarih
2009
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Medwell Online
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Bovine Amniotic Fluid (BAF) was topically applied for treatment group, whereas isotonic saline solution was applied for saline group in the study after an alkali burn was created in the right eye of 16 rats with 2.5 N NaOH. Density and area of the corneal opacity, area of the corneal epithelial defect, corneal neovascularization and complications were clinically evaluated and scored using a modified model at post-injury days 0, 3, 7 and 14. At the end of the experiment, all the eyes were histologically examined after enucleation. It was resultantly found that BAF has slightly decreased corneal opacification, increased reepithelization and limited neovascularization, hyphema and total corneal erosions. But these clinical ocular damage scores were not statistically significant. In histological examination, the number of polymorphonuclear leucocytes, corneal thicknesses, edema, keratinization, vascularization and inflammation were significantly reduced by BAF compared to the saline group. Based on these positive effects in severe burns, it was concluded that BAF could be a new topical alternative agent for veterinary ophthalmology thereafter.
Açıklama
Anahtar Kelimeler
Alkali burn, BAF, bovine amniotic fluid, cornea, rat
Kaynak
Journal of Animal and Veterinary Advances
WoS Q Değeri
Q4
Scopus Q Değeri
N/A
Cilt
8
Sayı
4
