The Protective Role of Dexpanthenol on the Endometrial Implants in an Experimentally Induced Rat Endometriosis Model
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Dosyalar
Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer Heidelberg
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: Dexpanthenol (Dxp), antioxidant and anti-inflammatory agent, plays an important role in the repair systems against oxidative stress and inflammatory response. The objective of this study is to determine the effect of Dxp on experimental endometriosis model. Study Design: A prospective experimental study was conducted in Experimental Animal Laboratory of Mustafa Kemal University, Hatay. Twenty nonpregnant female Wistar albino rats, in which experimental model of endometriosis was surgically induced, were randomly divided into 2 groups. Group 1 was administered 500 mg/kg/d Dxp intraperitoneally for 14 days, and group 2 was given the same amount of saline solution. After 2 weeks of medication, the rats were killed and implant volumes, histopathologic scores; and levels of serum total antioxidant status, total oxidant status (TOS), and oxidative stress index (OSI) were evaluated. Plasma and peritoneal fluid levels of tumor necrosis factor (TNF-) were analyzed. Results: The endometriotic implant volumes, histopathologic scores, and serum TOS and OSI values were significantly decreased (P < .05) in the Dxp group compared to the control group. Plasma and peritoneal fluid TNF- levels were significantly decreased (P < .05) in the Dxp group compared to the control group. Conclusion: Dexpanthenol has free radical scavenger effects, and antioxidant properties has significantly regressed endometriotic implant volumes, histopathologic scores, and serum TOS and OSI values. Serum and peritoneal fluid TNF- levels were significantly decreased in the Dxp group. So Dxp decreased oxidative stress.
Açıklama
Anahtar Kelimeler
endometriosis, dexpanthenol, oxidative stress
Kaynak
Reproductive Sciences
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
24
Sayı
2