The Protective Role of Dexpanthenol on the Endometrial Implants in an Experimentally Induced Rat Endometriosis Model

dc.contributor.authorKarapinar, Oya Soylu
dc.contributor.authorPinar, Neslihan
dc.contributor.authorOzgur, Tumay
dc.contributor.authorOzcan, Oguzhan
dc.contributor.authorBayraktar, H. Suphi
dc.contributor.authorKurt, Raziye Keskin
dc.contributor.authorNural, Orhan
dc.date.accessioned2024-09-18T20:16:52Z
dc.date.available2024-09-18T20:16:52Z
dc.date.issued2017
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: Dexpanthenol (Dxp), antioxidant and anti-inflammatory agent, plays an important role in the repair systems against oxidative stress and inflammatory response. The objective of this study is to determine the effect of Dxp on experimental endometriosis model. Study Design: A prospective experimental study was conducted in Experimental Animal Laboratory of Mustafa Kemal University, Hatay. Twenty nonpregnant female Wistar albino rats, in which experimental model of endometriosis was surgically induced, were randomly divided into 2 groups. Group 1 was administered 500 mg/kg/d Dxp intraperitoneally for 14 days, and group 2 was given the same amount of saline solution. After 2 weeks of medication, the rats were killed and implant volumes, histopathologic scores; and levels of serum total antioxidant status, total oxidant status (TOS), and oxidative stress index (OSI) were evaluated. Plasma and peritoneal fluid levels of tumor necrosis factor (TNF-) were analyzed. Results: The endometriotic implant volumes, histopathologic scores, and serum TOS and OSI values were significantly decreased (P < .05) in the Dxp group compared to the control group. Plasma and peritoneal fluid TNF- levels were significantly decreased (P < .05) in the Dxp group compared to the control group. Conclusion: Dexpanthenol has free radical scavenger effects, and antioxidant properties has significantly regressed endometriotic implant volumes, histopathologic scores, and serum TOS and OSI values. Serum and peritoneal fluid TNF- levels were significantly decreased in the Dxp group. So Dxp decreased oxidative stress.en_US
dc.description.sponsorshipMustafa Kemal University Scientific Research Project Coordination [13482]en_US
dc.description.sponsorshipThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The study was supported by Mustafa Kemal University Scientific Research Project Coordination (Project number: 13482).en_US
dc.identifier.doi10.1177/1933719116653682
dc.identifier.endpage290en_US
dc.identifier.issn1933-7191
dc.identifier.issn1933-7205
dc.identifier.issue2en_US
dc.identifier.pmid27313118en_US
dc.identifier.scopus2-s2.0-85011556663en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage285en_US
dc.identifier.urihttps://doi.org/10.1177/1933719116653682
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9788
dc.identifier.volume24en_US
dc.identifier.wosWOS:000394802500012en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofReproductive Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectendometriosisen_US
dc.subjectdexpanthenolen_US
dc.subjectoxidative stressen_US
dc.titleThe Protective Role of Dexpanthenol on the Endometrial Implants in an Experimentally Induced Rat Endometriosis Modelen_US
dc.typeArticleen_US

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