Relation of fragmented QRS to tissue Doppler-derived parametersin patients with familial Mediterranean fever
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Date
2015
Journal Title
Journal ISSN
Volume Title
Publisher
Springer Wien
Access Rights
info:eu-repo/semantics/closedAccess
Abstract
Familial Mediterranean fever (FMF) may pose a risk for cardiovascular diseases due to continuous inflammatory status observed during the course of the disease. Recently, the presence of fragmented QRS (fQRS) has been recognized as a predictor of myocardial fibrosis. In this study, we aim to investigate the frequency of fQRS and its relation to Doppler-based indices. This study consisted of 80 FMF patients and 30 healthy control subjects. fQRS pattern was defined as the presence of additional R waves or RSR', evidenced by notched R or S wave on electrocardiography (ECG). The patient and the control groups underwent conventional echocardiography and tissue Doppler echocardiography. There was no significant difference between groups regarding age (29 +/- 12 vs 29 +/- 15). FMF patients exhibited a statistically higher frequency of fQRS (% 56 vs % 13) (p < 0.01). E/Em ratio showed a statistically significant increase in the FMF group with fQRS (p < 0.0001), while the mean Em value was markedly lower (p < 0.0001). FMF patients displayed a statistically significant increase in frequency of fQRS. Doppler-derived diastolic index was statistically significantly impaired in FMF patients with fQRS as compared with the patients without fQRS. In conclusion, fQRS might be a new noninvasive marker for cardiac involvement in FMF patients.
Description
Keywords
Fragmented QRS, Familial Mediterranean fever, Tissue Doppler echocardiography
Journal or Series
Wiener Klinische Wochenschrift
WoS Q Value
Q3
Scopus Q Value
Q1
Volume
127
Issue
5-6
