Relation of fragmented QRS to tissue Doppler-derived parametersin patients with familial Mediterranean fever

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dc.contributor.authorCelik, Muhammet Murat
dc.contributor.authorBuyukkaya, Eyup
dc.contributor.authorUstun, Nilgul
dc.contributor.authorNacar, Alper Bugra
dc.contributor.authorKurt, Mustafa
dc.contributor.authorKarakas, Mehmet Fatih
dc.contributor.authorBilen, Perihan
dc.date.accessioned2024-09-18T20:25:13Z
dc.date.available2024-09-18T20:25:13Z
dc.date.issued2015
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractFamilial Mediterranean fever (FMF) may pose a risk for cardiovascular diseases due to continuous inflammatory status observed during the course of the disease. Recently, the presence of fragmented QRS (fQRS) has been recognized as a predictor of myocardial fibrosis. In this study, we aim to investigate the frequency of fQRS and its relation to Doppler-based indices. This study consisted of 80 FMF patients and 30 healthy control subjects. fQRS pattern was defined as the presence of additional R waves or RSR', evidenced by notched R or S wave on electrocardiography (ECG). The patient and the control groups underwent conventional echocardiography and tissue Doppler echocardiography. There was no significant difference between groups regarding age (29 +/- 12 vs 29 +/- 15). FMF patients exhibited a statistically higher frequency of fQRS (% 56 vs % 13) (p < 0.01). E/Em ratio showed a statistically significant increase in the FMF group with fQRS (p < 0.0001), while the mean Em value was markedly lower (p < 0.0001). FMF patients displayed a statistically significant increase in frequency of fQRS. Doppler-derived diastolic index was statistically significantly impaired in FMF patients with fQRS as compared with the patients without fQRS. In conclusion, fQRS might be a new noninvasive marker for cardiac involvement in FMF patients.en_US
dc.identifier.doi10.1007/s00508-015-0714-x
dc.identifier.endpage190en_US
dc.identifier.issn0043-5325
dc.identifier.issn1613-7671
dc.identifier.issue5-6en_US
dc.identifier.pmid25787212en_US
dc.identifier.scopus2-s2.0-84939940774en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage185en_US
dc.identifier.urihttps://doi.org/10.1007/s00508-015-0714-x
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10163
dc.identifier.volume127en_US
dc.identifier.wosWOS:000352865700002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Wienen_US
dc.relation.ispartofWiener Klinische Wochenschriften_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFragmented QRSen_US
dc.subjectFamilial Mediterranean feveren_US
dc.subjectTissue Doppler echocardiographyen_US
dc.titleRelation of fragmented QRS to tissue Doppler-derived parametersin patients with familial Mediterranean feveren_US
dc.typeArticleen_US

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