Platelet-Rich Plasma (PRP) is a Potential Self-Sourced Cognition Booster in Elderly Mice
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Date
2020
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Taylor & Francis Inc
Access Rights
info:eu-repo/semantics/closedAccess
Abstract
Background: A complex set of neurotrophic growth factors participates in neuroplasticity in the aging brain. Platelets are a copious source of growth factors, most of which display also the neurotropic activity. On this basis, we investigated behavioral and cognitive consequences of the administration of intravenous allogeneic platelet-rich plasma (PRP) in senescent mice. Methods: The animals (16-18 months old) were injected with either physiological saline or PRP which was acquired from age-matched counterparts and subjected to a battery of tests comprised of open-field, elevated-plus maze, tail suspension, and Morris water maze test. Results: We found that PRP treatment increases locomotion and improves learning and memory in elderly mice. Importantly, the PRP-treated animals did not exhibit any anxiety- or depression-like behaviors. Conclusion: The present study is the first to demonstrate that allogeneic PRP possesses beneficial effects against cognitive aging and it signifies that PRP may be used as a novel self-sourced treatment in age-related cognitive decline.
Description
Keywords
Growth-Factor-I, Age-Related Decline, Factors Prgf, Rat-Brain, Survival, Disease, Impact, Model, Igf-1, Neuroprotection
Journal or Series
Experimental Aging Research
WoS Q Value
Q4
Scopus Q Value
Q1
Volume
46
Issue
2
