Platelet-Rich Plasma (PRP) is a Potential Self-Sourced Cognition Booster in Elderly Mice

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dc.authoridDemir, Enver/0000-0002-2620-6192
dc.authoridKaragoz, Mehtap/0000-0002-9207-7384
dc.contributor.authorDemir, Enver Ahmet
dc.contributor.authorKaragoz, Mehtap
dc.date.accessioned2024-09-18T21:05:07Z
dc.date.available2024-09-18T21:05:07Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: A complex set of neurotrophic growth factors participates in neuroplasticity in the aging brain. Platelets are a copious source of growth factors, most of which display also the neurotropic activity. On this basis, we investigated behavioral and cognitive consequences of the administration of intravenous allogeneic platelet-rich plasma (PRP) in senescent mice. Methods: The animals (16-18 months old) were injected with either physiological saline or PRP which was acquired from age-matched counterparts and subjected to a battery of tests comprised of open-field, elevated-plus maze, tail suspension, and Morris water maze test. Results: We found that PRP treatment increases locomotion and improves learning and memory in elderly mice. Importantly, the PRP-treated animals did not exhibit any anxiety- or depression-like behaviors. Conclusion: The present study is the first to demonstrate that allogeneic PRP possesses beneficial effects against cognitive aging and it signifies that PRP may be used as a novel self-sourced treatment in age-related cognitive decline.en_US
dc.identifier.doi10.1080/0361073X.2020.1716154
dc.identifier.endpage153en_US
dc.identifier.issn0361-073X
dc.identifier.issn1096-4657
dc.identifier.issue2en_US
dc.identifier.pmid31939709en_US
dc.identifier.scopus2-s2.0-85078056215en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage139en_US
dc.identifier.urihttps://doi.org/10.1080/0361073X.2020.1716154
dc.identifier.urihttps://hdl.handle.net/20.500.12483/13378
dc.identifier.volume46en_US
dc.identifier.wosWOS:000507222100001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofExperimental Aging Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGrowth-Factor-Ien_US
dc.subjectAge-Related Declineen_US
dc.subjectFactors Prgfen_US
dc.subjectRat-Brainen_US
dc.subjectSurvivalen_US
dc.subjectDiseaseen_US
dc.subjectImpacten_US
dc.subjectModelen_US
dc.subjectIgf-1en_US
dc.subjectNeuroprotectionen_US
dc.titlePlatelet-Rich Plasma (PRP) is a Potential Self-Sourced Cognition Booster in Elderly Miceen_US
dc.typeArticleen_US

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