An Application of Cox Mixed Cure Model for Breast Cancer Patients

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dc.contributor.authorÇetin, Şirin
dc.contributor.authorPasin, Özge
dc.contributor.authorDede, İsa
dc.contributor.authorUlgen, Ayse
dc.date.accessioned2024-09-19T16:25:16Z
dc.date.available2024-09-19T16:25:16Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: Survival analyses are used in cancer research in the selection of treatment methods that may be effective in survival time and in investigating prognostic factors. In the literature, Cox regression analysis was performed without investigating whether the assumptions were met in survival analysis. The aim of this study is; to give information about the features of Cox mixed cure models and to show its application for breast cancer patients. Material and Methods: In our study, it was observed that breast cancer data did not provide the proportional hazard assumption. In addition, since the survival curve has a flattened tail after 72 months, this study was analyzed with a mixed cure model. In the model, cured and uncured patients are modeled separately. Results: In our study, the median survival time of the patients was found to be 72 months (95% confidence interval; 51.88-92.12). Progesterone receptor, estrogen receptor, c-erbB-2, age and lymph node were found to be a significant risk factor for the survival of breast cancer patients in cured and uncured part (for all of them p<0.05). Conclusion: Nowadays, cancer patients are more likely to recover. For this reason, we think that it would be appropriate to evaluate the survival analyses of cured and uncured cancer patients separately with a mixed cure model instead of Cox regression analysis in modeling the survival analysis of cancer patients.en_US
dc.identifier.doi10.5336/biostatic.2020-79287
dc.identifier.endpage137en_US
dc.identifier.issn1308-7894
dc.identifier.issn2146-8877
dc.identifier.issue2en_US
dc.identifier.startpage131en_US
dc.identifier.trdizinid491570en_US
dc.identifier.urihttps://doi.org/10.5336/biostatic.2020-79287
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/491570
dc.identifier.urihttps://hdl.handle.net/20.500.12483/16324
dc.identifier.volume13en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofTürkiye Klinikleri Biyoistatistik Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleAn Application of Cox Mixed Cure Model for Breast Cancer Patientsen_US
dc.typeArticleen_US

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